Detailed information of TA system TA114529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3187877..3188556
• Replicon: chromosome
• Accession: NZ_CP033862
• Organism: Acinetobacter sp. FDAARGOS_560

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: EG364_RS15585
• Protein ID: WP_000838146.1
• Coordinates: 3188374..3188556 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: EG364_RS15580
• Protein ID: WP_000966688.1
• Coordinates: 3187877..3188281 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EG364_RS15570	3186833..3187096	-	264	WP_001275792.1	hypothetical protein	-
EG364_RS15575	3187098..3187778	-	681	WP_000721572.1	hypothetical protein	-
EG364_RS15580	3187877..3188281	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EG364_RS15585	3188374..3188556	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
EG364_RS15595	3188882..3189397	-	516	WP_024616020.1	hypothetical protein	-
EG364_RS15600	3189468..3190385	-	918	WP_000094253.1	hypothetical protein	-
EG364_RS15605	3190438..3191793	-	1356	WP_000002415.1	hypothetical protein	-
EG364_RS15610	3191793..3192146	-	354	WP_000064593.1	hypothetical protein	-
EG364_RS15615	3192243..3192763	-	521	Protein_3020	SH3 domain-containing protein	-
EG364_RS15620	3192872..3193090	-	219	WP_001277696.1	hypothetical protein	-
EG364_RS15625	3193092..3193535	-	444	WP_002016455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3169401..3224483	55082

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T114529 WP_000838146.1 NZ_CP033862:c3188556-3188374 [Acinetobacter sp. FDAARGOS_560]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T114529 NZ_CP033862:c3188556-3188374 [Acinetobacter sp. FDAARGOS_560]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT114529 WP_000966688.1 NZ_CP033862:c3188281-3187877 [Acinetobacter sp. FDAARGOS_560]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT114529 NZ_CP033862:c3188281-3187877 [Acinetobacter sp. FDAARGOS_560]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6