Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2658920..2659571 Replicon chromosome
Accession NZ_CP033862
Organism Acinetobacter sp. FDAARGOS_560

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag EG364_RS13075 Protein ID WP_000838146.1
Coordinates 2659389..2659571 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag EG364_RS13070 Protein ID WP_000966689.1
Coordinates 2658920..2659324 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EG364_RS13055 2653953..2654294 - 342 WP_001281459.1 phage tail protein -
EG364_RS13060 2654412..2658377 - 3966 WP_000191304.1 tape measure protein -
EG364_RS13065 2658438..2658839 - 402 WP_000720591.1 hypothetical protein -
EG364_RS13070 2658920..2659324 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EG364_RS13075 2659389..2659571 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
EG364_RS13080 2659903..2660436 - 534 WP_001185622.1 hypothetical protein -
EG364_RS13085 2660481..2661410 - 930 WP_000094300.1 hypothetical protein -
EG364_RS13090 2661518..2661730 - 213 WP_000121166.1 hypothetical protein -
EG364_RS13095 2661732..2662130 - 399 WP_001132270.1 hypothetical protein -
EG364_RS13100 2662132..2662500 - 369 WP_000539752.1 hypothetical protein -
EG364_RS13105 2662472..2662876 - 405 WP_000248324.1 hypothetical protein -
EG364_RS13110 2662885..2663253 - 369 WP_000524231.1 hypothetical protein -
EG364_RS13115 2663255..2663644 - 390 WP_000008492.1 hypothetical protein -
EG364_RS13120 2663649..2664314 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2635349..2700498 65149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T114528 WP_000838146.1 NZ_CP033862:c2659571-2659389 [Acinetobacter sp. FDAARGOS_560]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T114528 NZ_CP033862:c2659571-2659389 [Acinetobacter sp. FDAARGOS_560]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT114528 WP_000966689.1 NZ_CP033862:c2659324-2658920 [Acinetobacter sp. FDAARGOS_560]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT114528 NZ_CP033862:c2659324-2658920 [Acinetobacter sp. FDAARGOS_560]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References