Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 566680..567515 Replicon chromosome
Accession NZ_CP033850
Organism Escherichia coli strain FDAARGOS_497

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A1A9A5
Locus tag EGY17_RS04605 Protein ID WP_001564063.1
Coordinates 567138..567515 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A1AEL8
Locus tag EGY17_RS04600 Protein ID WP_038432125.1
Coordinates 566680..567048 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY17_RS04565 562339..563019 + 681 WP_001278649.1 WYL domain-containing protein -
EGY17_RS04570 563170..563847 + 678 WP_001564058.1 hypothetical protein -
EGY17_RS04575 563853..564086 + 234 WP_001278293.1 DUF905 family protein -
EGY17_RS04580 564176..564994 + 819 WP_001175165.1 DUF945 domain-containing protein -
EGY17_RS04585 565260..565739 + 480 WP_001564060.1 antirestriction protein -
EGY17_RS04590 565755..566231 + 477 WP_021553055.1 RadC family protein -
EGY17_RS04595 566296..566517 + 222 WP_000692345.1 DUF987 domain-containing protein -
EGY17_RS04600 566680..567048 + 369 WP_038432125.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EGY17_RS04605 567138..567515 + 378 WP_001564063.1 TA system toxin CbtA family protein Toxin
EGY17_RS27660 567512..567661 + 150 Protein_528 hypothetical protein -
EGY17_RS27665 567740..567934 + 195 WP_024181941.1 DUF957 domain-containing protein -
EGY17_RS04620 568019..568861 + 843 Protein_530 DUF4942 domain-containing protein -
EGY17_RS04625 569203..569373 + 171 Protein_531 IS110 family transposase -
EGY17_RS04630 570184..571167 + 984 WP_001361242.1 KpsF/GutQ family sugar-phosphate isomerase -
EGY17_RS04635 571239..572387 + 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - papX 502433..568988 66555
- flank IS/Tn - - 569269..569373 104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14094.09 Da        Isoelectric Point: 7.8045

>T114490 WP_001564063.1 NZ_CP033850:567138-567515 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T114490 NZ_CP033850:567138-567515 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13569.31 Da        Isoelectric Point: 7.0369

>AT114490 WP_038432125.1 NZ_CP033850:566680-567048 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT114490 NZ_CP033850:566680-567048 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1A9A5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AEL8

References