Detailed information of TA system TA114479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4741273..4742092
• Replicon: chromosome
• Accession: NZ_CP033844
• Organism: Klebsiella oxytoca strain FDAARGOS_500

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: EGY21_RS22740
• Protein ID: WP_004110819.1
• Coordinates: 4741273..4741530 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: EGY21_RS22745
• Protein ID: WP_016809596.1
• Coordinates: 4741541..4742092 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY21_RS22725	4737045..4737821	-	777	WP_004099223.1	Uxu operon transcriptional regulator	-
EGY21_RS22730	4737957..4739432	-	1476	WP_123830182.1	fructuronate reductase	-
EGY21_RS22735	4739507..4740691	-	1185	WP_004099225.1	mannonate dehydratase	-
EGY21_RS22740	4741273..4741530	+	258	WP_004110819.1	YjhX family toxin	Toxin
EGY21_RS22745	4741541..4742092	+	552	WP_016809596.1	N-acetyltransferase	Antitoxin
EGY21_RS22750	4742110..4743738	+	1629	WP_023329287.1	SAM-dependent methyltransferase	-
EGY21_RS22755	4743784..4744947	-	1164	WP_024273763.1	MFS transporter	-
EGY21_RS22760	4744965..4746242	-	1278	WP_123830183.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T114479 WP_004110819.1 NZ_CP033844:4741273-4741530 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T114479 NZ_CP033844:4741273-4741530 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGACTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20169.01 Da
• Isoelectric Point: 6.8799

>AT114479 WP_016809596.1 NZ_CP033844:4741541-4742092 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT114479 NZ_CP033844:4741541-4742092 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGATCTGGTTGCCGCTTTGCTCAACGATGAAAGTGCTCACCCGAGCTTATCTCTGCTGGCCA
AACATAATGGAAAAGCCGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCCCTGGCGGTGGTGCCGGAATACCAGGGCGTGGGCGTAGGCGGATTGCTTATCCAGCGCGGTATTGAGCA
TCTGAAAGCCGCAGGAAGCGAGGCGGTATTTGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGAGAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2