Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2532009..2532514 Replicon chromosome
Accession NZ_CP033843
Organism Pseudomonas aeruginosa strain FDAARGOS_501

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag EGY29_RS12030 Protein ID WP_003083773.1
Coordinates 2532233..2532514 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EGY29_RS12025 Protein ID WP_003083775.1
Coordinates 2532009..2532236 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY29_RS12000 2527027..2528520 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
EGY29_RS12005 2528689..2530116 + 1428 WP_003083784.1 GABA permease -
EGY29_RS12010 2530198..2530539 - 342 WP_014603467.1 alkylphosphonate utilization protein -
EGY29_RS12015 2530612..2531112 - 501 WP_003083778.1 LEA type 2 family protein -
EGY29_RS12020 2531213..2531833 + 621 WP_123788638.1 hypothetical protein -
EGY29_RS12025 2532009..2532236 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EGY29_RS12030 2532233..2532514 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
EGY29_RS12035 2532814..2533722 + 909 WP_003083769.1 LysR family transcriptional regulator -
EGY29_RS12040 2533754..2534140 - 387 WP_003083767.1 aegerolysin family protein -
EGY29_RS12045 2534344..2535078 - 735 WP_003083764.1 GntR family transcriptional regulator -
EGY29_RS12050 2535179..2535865 - 687 WP_003083762.1 FadR family transcriptional regulator -
EGY29_RS12055 2535914..2537263 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T114464 WP_003083773.1 NZ_CP033843:2532233-2532514 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T114464 NZ_CP033843:2532233-2532514 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT114464 WP_003083775.1 NZ_CP033843:2532009-2532236 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT114464 NZ_CP033843:2532009-2532236 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGATGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References