Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1210687..1211253 Replicon chromosome
Accession NZ_CP033841
Organism Bifidobacterium breve strain FDAARGOS_561

Toxin (Protein)


Gene name relE Uniprot ID D4BPQ4
Locus tag EGX97_RS05480 Protein ID WP_003829417.1
Coordinates 1210960..1211253 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag EGX97_RS05475 Protein ID WP_014483711.1
Coordinates 1210687..1210956 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX97_RS05450 1206436..1207131 - 696 WP_003829410.1 response regulator transcription factor -
EGX97_RS05455 1207257..1207772 + 516 WP_013140733.1 hypothetical protein -
EGX97_RS05460 1207769..1208659 + 891 WP_003829412.1 hypothetical protein -
EGX97_RS05465 1208656..1209336 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
EGX97_RS05470 1209333..1210502 + 1170 WP_050755802.1 ABC transporter permease -
EGX97_RS05475 1210687..1210956 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EGX97_RS05480 1210960..1211253 + 294 WP_003829417.1 type II toxin-antitoxin system YafQ family toxin Toxin
EGX97_RS10435 1211259..1211558 - 300 WP_003829418.1 hypothetical protein -
EGX97_RS05490 1211921..1212472 + 552 WP_050755804.1 RNA polymerase sigma factor -
EGX97_RS05495 1212506..1213333 + 828 WP_003829422.1 hypothetical protein -
EGX97_RS05500 1213466..1214092 + 627 WP_003829423.1 hypothetical protein -
EGX97_RS05505 1214089..1214871 + 783 WP_003829424.1 hypothetical protein -
EGX97_RS05510 1214924..1215799 + 876 WP_003829425.1 ABC transporter ATP-binding protein -
EGX97_RS05515 1215853..1216251 + 399 WP_003829426.1 superoxide dismutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1204589..1230120 25531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.92 Da        Isoelectric Point: 9.8306

>T114461 WP_003829417.1 NZ_CP033841:1210960-1211253 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGR

Download         Length: 294 bp

>T114461 NZ_CP033841:1210960-1211253 [Bifidobacterium breve]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACGCTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTGCTTGAGGACACGGCGGACTCCAAGGAAGCATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATCTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT114461 WP_014483711.1 NZ_CP033841:1210687-1210956 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT114461 NZ_CP033841:1210687-1210956 [Bifidobacterium breve]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCTCTAAACCTTTCCTATACGA
CCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAAAACAGGCTCGCCGACGGCAAACCTCGTTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7C7H2

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References