Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2059850..2061594 Replicon chromosome
Accession NZ_CP033838
Organism Burkholderia dolosa strain FDAARGOS_562

Toxin (Protein)


Gene name doc Uniprot ID A0A892IG78
Locus tag EGY28_RS09255 Protein ID WP_006766124.1
Coordinates 2059850..2060740 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A892IEP8
Locus tag EGY28_RS09260 Protein ID WP_006766123.1
Coordinates 2060737..2061594 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY28_RS09225 2055227..2056306 - 1080 WP_035974291.1 porin -
EGY28_RS09230 2056751..2057068 + 318 WP_006766129.1 non-heme iron oxygenase ferredoxin subunit -
EGY28_RS09235 2057070..2057381 + 312 WP_006766128.1 hypothetical protein -
EGY28_RS09240 2057443..2058513 + 1071 WP_006766127.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
EGY28_RS09245 2058506..2059276 + 771 WP_035975317.1 SDR family oxidoreductase -
EGY28_RS09250 2059304..2059831 + 528 WP_035975316.1 cupin domain-containing protein -
EGY28_RS09255 2059850..2060740 + 891 WP_006766124.1 alpha/beta fold hydrolase Toxin
EGY28_RS09260 2060737..2061594 + 858 WP_006766123.1 IclR family transcriptional regulator Antitoxin
EGY28_RS09265 2061674..2062471 + 798 WP_035974289.1 SDR family oxidoreductase -
EGY28_RS09270 2062464..2064131 + 1668 WP_035974287.1 thiamine pyrophosphate-binding protein -
EGY28_RS09275 2064124..2064951 + 828 WP_006766122.1 aspartate dehydrogenase -
EGY28_RS09280 2065043..2066533 + 1491 WP_035974286.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-276)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 30188.38 Da        Isoelectric Point: 6.6302

>T114458 WP_006766124.1 NZ_CP033838:2059850-2060740 [Burkholderia dolosa]
MTVIEKRERAAAFAALLEQFPEQRCAAGAAGTIGYREAGAQQADRALPVVLLHGIGSGAASWVRQLDALGAVRRVLAWDA
PGYGASTPVRAASPVAADYAAALDAWLDALGIERCVVVGHSLGAIVAGGMVSAMPARIAGLLLISPAGGYGSASADTRNA
RRDARLAMLAALGPAGLAEQRSGNMLSGFASDDARAWVRWNMARIVPDGYAQATHLLANADLAADVAGFAGHAAVAVGAN
DAITPPAACERIAAALGVELQVVPQAGHAGYVEAPAIYSALIDAFCRSCDTQRRPA

Download         Length: 891 bp

>T114458 NZ_CP033838:2059850-2060740 [Burkholderia dolosa]
ATGACCGTCATCGAAAAGCGCGAACGCGCAGCGGCTTTCGCCGCGCTGCTCGAGCAGTTTCCGGAGCAGCGCTGCGCGGC
CGGTGCGGCCGGCACGATCGGCTATCGCGAGGCCGGCGCGCAGCAAGCGGACCGTGCGCTGCCCGTCGTGCTGCTGCACG
GAATCGGCTCGGGCGCCGCATCGTGGGTGCGTCAGCTCGATGCGCTCGGCGCGGTGCGCCGCGTGCTCGCGTGGGACGCG
CCCGGCTACGGCGCATCGACGCCGGTGCGCGCGGCATCGCCGGTCGCCGCCGATTACGCGGCCGCGCTGGATGCGTGGCT
TGACGCGCTCGGCATCGAGCGCTGCGTGGTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGCATGGTGAGCGCGA
TGCCGGCGCGAATCGCCGGGTTGCTGCTGATCTCGCCGGCGGGCGGCTACGGCAGCGCGAGCGCCGATACGCGCAACGCG
CGCCGCGACGCGCGGCTCGCGATGCTCGCGGCGCTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAATATGCTGTC
CGGCTTCGCGAGCGACGATGCGCGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGACGGCTACGCGCAGGCGA
CGCATCTGCTCGCGAACGCCGATCTGGCGGCCGACGTCGCCGGTTTCGCCGGTCATGCGGCGGTGGCCGTCGGTGCAAAC
GACGCGATCACGCCGCCCGCTGCATGCGAACGGATCGCGGCGGCGCTCGGCGTCGAACTGCAGGTGGTTCCGCAGGCCGG
CCACGCCGGTTACGTCGAAGCGCCGGCCATCTATTCCGCGCTGATCGACGCGTTCTGCCGATCGTGCGACACGCAGCGGA
GGCCCGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31426.97 Da        Isoelectric Point: 8.0592

>AT114458 WP_006766123.1 NZ_CP033838:2060737-2061594 [Burkholderia dolosa]
MSAPLQRQAADDAKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYR
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLQELYALYPERTLNRMTSATPETVDALYEAIREDARRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFMKALGLK

Download         Length: 858 bp

>AT114458 NZ_CP033838:2060737-2061594 [Burkholderia dolosa]
ATGAGCGCGCCGCTGCAACGCCAGGCAGCCGACGACGCGAAGGCCGATGCCGGCTACGTCGTGCCGGGGCTCGAGCGCGG
GCTGCGGATTCTCGCGGAGTTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGTATTCCGC
GCACGACGGTGTTTCGCCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGACCGGAACTACCGG
CTCGGCATCGCGGTGCTGCGGCTCGGCTTCGAGTATCTGAGCTCGCTCGAGCTGACCGATCTCGGGCTGCCCGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGC
AAAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGCTGCAGGAGCTGTACGCGCTGTATCCGGAGCGCACGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTCGATGCGCTGTACGAAGCGATCCGCGAAGACGCACGGCGCGGCTACGGGATCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGCCCCGAAATCGACGCGACGCTGATCGCGGACGGACTGATCGACAAGGTGCGGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTCATGAAGGCTTTGGGACTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References