Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1460264..1460757 Replicon chromosome
Accession NZ_CP033837
Organism Fusobacterium necrophorum strain FDAARGOS_565

Toxin (Protein)


Gene name relE Uniprot ID A0A654S0Z3
Locus tag EGX98_RS06820 Protein ID WP_035934308.1
Coordinates 1460264..1460530 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W0H3
Locus tag EGX98_RS06825 Protein ID WP_005955951.1
Coordinates 1460527..1460757 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX98_RS06800 1455386..1457428 - 2043 WP_035934313.1 ATP-dependent DNA helicase RecG -
EGX98_RS06805 1457470..1458219 - 750 WP_035934312.1 YebC/PmpR family DNA-binding transcriptional regulator -
EGX98_RS06810 1458251..1459552 - 1302 WP_035934311.1 MATE family efflux transporter -
EGX98_RS06820 1460264..1460530 - 267 WP_035934308.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX98_RS06825 1460527..1460757 - 231 WP_005955951.1 hypothetical protein Antitoxin
EGX98_RS06830 1461260..1461778 + 519 WP_005957007.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
EGX98_RS06835 1461904..1462878 + 975 WP_074517958.1 D-glycero-beta-D-manno-heptose-7-phosphate kinase -
EGX98_RS06840 1462894..1463370 + 477 WP_035901061.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
EGX98_RS06845 1463413..1465080 + 1668 WP_035934298.1 tetratricopeptide repeat protein -
EGX98_RS06850 1465205..1465516 + 312 WP_005955931.1 50S ribosomal protein L21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10578.46 Da        Isoelectric Point: 10.0801

>T114455 WP_035934308.1 NZ_CP033837:c1460530-1460264 [Fusobacterium necrophorum]
MKYRMEFSQQGKKELKKLDAFTQKIIMKWICKNLIDTENPTIHGKELKGNLKCFWRYRVGNYRLLADIQDETVTILSIKI
GHRKEIYE

Download         Length: 267 bp

>T114455 NZ_CP033837:c1460530-1460264 [Fusobacterium necrophorum]
ATGAAATACCGAATGGAATTTTCACAACAAGGAAAAAAGGAATTGAAAAAATTAGATGCCTTTACTCAAAAAATTATTAT
GAAGTGGATCTGTAAAAATCTAATTGATACGGAAAATCCAACAATACATGGAAAAGAACTAAAGGGAAACTTAAAGTGCT
TTTGGCGTTATCGTGTCGGAAATTACAGGTTATTAGCCGATATTCAAGACGAAACGGTAACCATTTTATCAATCAAAATA
GGACACAGAAAAGAAATTTATGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9012.25 Da        Isoelectric Point: 4.3363

>AT114455 WP_005955951.1 NZ_CP033837:c1460757-1460527 [Fusobacterium necrophorum]
MSIISLRLNEKEEKLLREFSAFEGLGISSYIKKIIYERLEDEYDIKCFDKAYQEYLESGKKSYSFDEVLNELGIEL

Download         Length: 231 bp

>AT114455 NZ_CP033837:c1460757-1460527 [Fusobacterium necrophorum]
ATGTCTATTATTTCTTTACGACTAAATGAAAAAGAAGAAAAATTATTAAGAGAATTCTCAGCATTTGAGGGCTTGGGAAT
CTCCTCATATATCAAAAAAATTATCTATGAAAGATTAGAGGATGAGTATGATATTAAATGTTTTGATAAAGCATATCAGG
AATATCTGGAAAGTGGAAAAAAATCATATTCTTTTGATGAAGTTTTAAATGAATTGGGAATTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A654S0Z3

Antitoxin

Source ID Structure
AlphaFold DB J5W0H3

References