Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezT-sezA/zeta-HTH_XRE
Location 1640467..1641768 Replicon chromosome
Accession NZ_CP033836
Organism Gardnerella vaginalis strain FDAARGOS_568

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag EGX90_RS07145 Protein ID WP_004117266.1
Coordinates 1640467..1641276 (-) Length 270 a.a.

Antitoxin (Protein)


Gene name sezA Uniprot ID -
Locus tag EGX90_RS07150 Protein ID WP_004117264.1
Coordinates 1641295..1641768 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX90_RS07125 1636373..1637110 + 738 WP_004112993.1 thiamine diphosphokinase -
EGX90_RS07130 1637286..1638341 + 1056 WP_004112995.1 type I glyceraldehyde-3-phosphate dehydrogenase -
EGX90_RS07135 1638452..1638952 + 501 WP_004112997.1 Cys-tRNA(Pro) deacylase -
EGX90_RS07140 1639000..1639959 + 960 WP_075038749.1 aldose 1-epimerase family protein -
EGX90_RS07145 1640467..1641276 - 810 WP_004117266.1 zeta toxin family protein Toxin
EGX90_RS07150 1641295..1641768 - 474 WP_004117264.1 helix-turn-helix domain-containing protein Antitoxin
EGX90_RS07160 1642304..1643692 - 1389 WP_102990843.1 hypothetical protein -
EGX90_RS07165 1644549..1645559 + 1011 WP_004116755.1 UDP-glucose 4-epimerase GalE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(34-221)

Antitoxin

Cro/C1-type helix-turn-helix domain

(6-59)


Sequences

Toxin        


Download         Length: 270 a.a.        Molecular weight: 30937.75 Da        Isoelectric Point: 8.8246

>T114454 WP_004117266.1 NZ_CP033836:c1641276-1640467 [Gardnerella vaginalis]
MGKCDFAMVIEDFSEEYFTHCLLRNLRSLQMYKHADLHPKAVLLGCQSGAGKTTIHVIKQKEFNGNIIILDADSYRTQHP
YYCELLDKYGKESVKYTSAFSAKMVRSLIDELSSKKYNLIIEGTLRSVEVPSSTAKMLIDRGYRVSLAVIATKPELSWIS
TLIRYREMYLEDPKSARATPKDHHDNIVNNIVDNLLKLEQSKIFDRIQIYKRDEKCIYDSDSYKNSPNITAASVLKEVLF
GKKTIDEKKLICHAKNRLNELDKLIDKSL

Download         Length: 810 bp

>T114454 NZ_CP033836:c1641276-1640467 [Gardnerella vaginalis]
ATGGGTAAGTGTGATTTTGCTATGGTTATAGAAGATTTTAGCGAAGAGTATTTTACTCACTGTTTGTTAAGAAATTTACG
TTCTTTACAAATGTATAAGCATGCAGATTTGCATCCTAAGGCGGTTTTACTCGGTTGTCAAAGTGGTGCTGGCAAAACGA
CCATTCATGTAATAAAACAAAAAGAATTTAACGGTAACATAATAATCCTTGATGCTGATAGCTATAGGACTCAACACCCT
TATTATTGCGAGTTGCTTGATAAATACGGTAAAGAAAGTGTTAAATATACGAGTGCTTTTTCAGCAAAAATGGTAAGAAG
CTTAATTGATGAGTTAAGTTCTAAAAAATATAATCTCATAATTGAAGGTACTTTGCGCAGTGTTGAAGTGCCTAGCAGCA
CTGCAAAAATGTTGATAGATCGCGGTTACCGTGTTTCTCTTGCTGTCATCGCAACAAAACCTGAATTGTCATGGATCAGT
ACACTGATTCGCTACAGGGAAATGTATTTGGAAGATCCTAAAAGTGCTAGGGCAACTCCTAAGGATCATCACGACAATAT
TGTGAACAATATAGTAGATAACTTGTTGAAATTAGAACAATCGAAAATATTTGACAGAATTCAGATTTACAAGCGAGACG
AAAAATGTATATATGATTCTGATTCGTATAAAAATAGTCCAAATATTACAGCAGCTAGTGTTCTTAAGGAAGTGCTCTTT
GGCAAGAAAACTATTGATGAGAAAAAGTTGATTTGCCACGCTAAGAATAGGTTGAATGAACTAGACAAGTTGATAGATAA
AAGTTTGTAG

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 18020.51 Da        Isoelectric Point: 5.3525

>AT114454 WP_004117264.1 NZ_CP033836:c1641768-1641295 [Gardnerella vaginalis]
MVSVNIRALRRSKKLTQQELAEVLGVSRNSIVRYENGTSAISTRLIDKICNKFKVSLFDIVNEKELSASDKYDLNMKIEV
LKERGALLLARLYKYEDSMNIQFDDSSNAWIAISDDLSDVINTKIYTSTNFEDINRYIGYLDGIERLLEYVSCNKNS

Download         Length: 474 bp

>AT114454 NZ_CP033836:c1641768-1641295 [Gardnerella vaginalis]
ATGGTTTCTGTGAATATTCGAGCACTACGTCGCTCAAAAAAACTAACTCAACAAGAGTTAGCTGAAGTATTAGGAGTATC
TCGTAACAGCATTGTGCGATACGAAAATGGTACAAGTGCTATTTCAACTAGGTTAATAGATAAGATTTGTAATAAATTCA
AGGTTTCTCTTTTTGATATCGTAAATGAAAAAGAATTATCTGCATCTGATAAATACGATTTGAACATGAAGATTGAAGTT
TTAAAGGAGCGTGGCGCACTTTTACTGGCTCGTTTATATAAATACGAGGATAGTATGAATATACAATTTGATGATTCTTC
TAATGCGTGGATTGCAATTAGTGATGATTTATCAGATGTAATTAATACAAAGATTTATACATCTACAAATTTTGAAGATA
TAAATCGTTATATCGGATATTTAGATGGCATAGAACGCTTGCTTGAATACGTAAGTTGCAATAAAAATAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References