Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1577505..1578010 Replicon chromosome
Accession NZ_CP033832
Organism Pseudomonas aeruginosa strain FDAARGOS_505

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag EGY23_RS07405 Protein ID WP_003121619.1
Coordinates 1577505..1577786 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EGY23_RS07410 Protein ID WP_003083775.1
Coordinates 1577783..1578010 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY23_RS07380 1572756..1574105 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
EGY23_RS07385 1574154..1574840 + 687 WP_003083762.1 FadR family transcriptional regulator -
EGY23_RS07390 1574941..1575675 + 735 WP_003117208.1 GntR family transcriptional regulator -
EGY23_RS07395 1575879..1576265 + 387 WP_014602345.1 aegerolysin family protein -
EGY23_RS07400 1576297..1577205 - 909 WP_023083551.1 LysR family transcriptional regulator -
EGY23_RS07405 1577505..1577786 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
EGY23_RS07410 1577783..1578010 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EGY23_RS07415 1578186..1578806 - 621 WP_003101226.1 hypothetical protein -
EGY23_RS07420 1578907..1579407 + 501 WP_003101228.1 LEA type 2 family protein -
EGY23_RS07425 1579480..1579821 + 342 WP_003101229.1 alkylphosphonate utilization protein -
EGY23_RS07430 1579903..1581330 - 1428 WP_003083784.1 GABA permease -
EGY23_RS07435 1581499..1582992 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T114434 WP_003121619.1 NZ_CP033832:c1577786-1577505 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T114434 NZ_CP033832:c1577786-1577505 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT114434 WP_003083775.1 NZ_CP033832:c1578010-1577783 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT114434 NZ_CP033832:c1578010-1577783 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References