Detailed information of TA system TA114430

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4360230..4360858
• Replicon: chromosome
• Accession: NZ_CP033831
• Organism: Serratia sp. FDAARGOS_506

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EGY12_RS21060
• Protein ID: WP_123895254.1
• Coordinates: 4360230..4360433 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EGY12_RS21065
• Protein ID: WP_123895255.1
• Coordinates: 4360445..4360858 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY12_RS21055	4356095..4360066	+	3972	WP_123895253.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
EGY12_RS21060	4360230..4360433	+	204	WP_123895254.1	type II toxin-antitoxin system HicA family toxin	Toxin
EGY12_RS21065	4360445..4360858	+	414	WP_123895255.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EGY12_RS21070	4360888..4361640	-	753	WP_049197983.1	L-cystine ABC transporter ATP-binding protein YecC	-
EGY12_RS21075	4361644..4362306	-	663	WP_041035592.1	cystine ABC transporter permease	-
EGY12_RS21080	4362306..4363106	-	801	WP_123895256.1	cystine ABC transporter substrate-binding protein	-
EGY12_RS21085	4363222..4364214	-	993	WP_123895257.1	D-cysteine desulfhydrase	-
EGY12_RS21090	4364341..4364850	-	510	WP_004934751.1	flagella biosynthesis regulatory protein FliZ	-
EGY12_RS21095	4364905..4365627	-	723	WP_110158021.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliZ / fliA / fliS	4354039..4371954	17915

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7467.87 Da
• Isoelectric Point: 11.1475

>T114430 WP_123895254.1 NZ_CP033831:4360230-4360433 [Serratia sp. FDAARGOS_506]
VKSAELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPPPKKDLKLGTLRQILKDAGLSALHIATR

Nucleotide

• Length: 204 bp

>T114430 NZ_CP033831:4360230-4360433 [Serratia sp. FDAARGOS_506]
GTGAAGAGTGCAGAACTGATTGCGTTACTGGAAAGCCACGGTTGGGTATTGCGGCGGGTAAAAGGTAGCCACCATCAATT
CAAACATCCCGATTTTGCGCTGATCATCACCGTACCGCCCCCAAAGAAAGATCTAAAGCTGGGCACGCTGCGGCAGATAC
TTAAAGACGCGGGGTTGAGTGCGCTTCACATCGCCACGCGTTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14863.66 Da
• Isoelectric Point: 5.5169

>AT114430 WP_123895255.1 NZ_CP033831:4360445-4360858 [Serratia sp. FDAARGOS_506]
MFYPAYIHTESNGSASGFFPDVPGCYFAGASLDDAFIDAQSALDAHFELLSEDNQPIPRPHAVAAHLAKGAGSFEGGQWL
LVAINMDKFDGRAERINITLPQRLLSRIDSLVRQHPGYGSRSGFLAAAARNELLKTE

Nucleotide

• Length: 414 bp

>AT114430 NZ_CP033831:4360445-4360858 [Serratia sp. FDAARGOS_506]
ATGTTTTATCCCGCTTATATCCATACAGAGTCAAACGGCAGCGCCAGCGGTTTCTTTCCCGACGTCCCTGGCTGCTACTT
CGCCGGCGCTAGCCTGGACGACGCTTTTATCGATGCCCAAAGCGCACTGGATGCGCACTTTGAGTTGTTGAGCGAAGACA
ATCAACCGATACCGCGCCCGCATGCCGTCGCTGCCCATCTTGCCAAAGGTGCGGGCTCTTTCGAGGGTGGACAATGGTTA
TTGGTCGCTATCAATATGGATAAATTTGACGGTCGGGCCGAACGGATTAACATCACCTTGCCCCAGCGCCTGTTAAGTCG
CATTGACTCTCTGGTTCGGCAACATCCAGGATACGGCAGCCGCAGCGGGTTTCTCGCCGCCGCTGCGCGAAACGAATTAT
TGAAAACTGAGTGA