114421

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2521875..2522497 Replicon chromosome
Accession NZ_CP033831
Organism Serratia sp. FDAARGOS_506

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag EGY12_RS12225 Protein ID WP_004940313.1
Coordinates 2521875..2522078 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag EGY12_RS12230 Protein ID WP_004940312.1
Coordinates 2522129..2522497 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY12_RS12195 2517594..2517932 + 339 WP_004940327.1 P-II family nitrogen regulator -
EGY12_RS12200 2517969..2519255 + 1287 WP_123893812.1 ammonium transporter AmtB -
EGY12_RS12205 2519348..2520211 - 864 WP_123893813.1 acyl-CoA thioesterase II -
EGY12_RS12210 2520443..2520934 + 492 WP_016928846.1 YbaY family lipoprotein -
EGY12_RS12215 2520999..2521313 - 315 WP_033642088.1 MGMT family protein -
EGY12_RS12225 2521875..2522078 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
EGY12_RS12230 2522129..2522497 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
EGY12_RS12235 2522656..2523009 - 354 WP_123893814.1 hypothetical protein -
EGY12_RS12240 2523416..2524129 + 714 WP_123893815.1 ABC transporter ATP-binding protein -
EGY12_RS12245 2524126..2524983 + 858 WP_123893816.1 metal ABC transporter permease -
EGY12_RS12250 2525009..2525887 + 879 WP_123893817.1 metal ABC transporter substrate-binding protein -
EGY12_RS12255 2525994..2526134 - 141 WP_073529259.1 type B 50S ribosomal protein L36 -
EGY12_RS12260 2526147..2526401 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T114421 WP_004940313.1 NZ_CP033831:c2522078-2521875 [Serratia sp. FDAARGOS_506]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T114421 NZ_CP033831:c2522078-2521875 [Serratia sp. FDAARGOS_506]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAACTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCTGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT114421 WP_004940312.1 NZ_CP033831:c2522497-2522129 [Serratia sp. FDAARGOS_506]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT114421 NZ_CP033831:c2522497-2522129 [Serratia sp. FDAARGOS_506]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGTGACAGCCACCACGGGTGGGTCAACGATCCGACATCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCCGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTATTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References