Detailed information of TA system TA114420

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1576631..1577166
• Replicon: chromosome
• Accession: NZ_CP033831
• Organism: Serratia sp. FDAARGOS_506

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: EGY12_RS07730
• Protein ID: WP_033636570.1
• Coordinates: 1576891..1577166 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: EGY12_RS07725
• Protein ID: WP_033639076.1
• Coordinates: 1576631..1576891 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY12_RS07705	1571956..1572606	+	651	WP_049274320.1	DcrB-related protein	-
EGY12_RS07710	1572642..1573247	+	606	WP_123893046.1	glutathione S-transferase	-
EGY12_RS07715	1573316..1574710	+	1395	WP_123893047.1	L-seryl-tRNA(Sec) selenium transferase	-
EGY12_RS07720	1574707..1576548	+	1842	WP_123893048.1	selenocysteine-specific translation elongation factor	-
EGY12_RS07725	1576631..1576891	+	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
EGY12_RS07730	1576891..1577166	+	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGY12_RS07735	1577178..1578089	-	912	WP_123893049.1	LysR family transcriptional regulator	-
EGY12_RS07740	1578211..1578837	+	627	WP_123893050.1	LysE family translocator	-
EGY12_RS07745	1578891..1580138	-	1248	WP_049202603.1	MFS transporter	-
EGY12_RS07750	1580356..1581348	+	993	WP_123893051.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T114420 WP_033636570.1 NZ_CP033831:1576891-1577166 [Serratia sp. FDAARGOS_506]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T114420 NZ_CP033831:1576891-1577166 [Serratia sp. FDAARGOS_506]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCTGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT114420 WP_033639076.1 NZ_CP033831:1576631-1576891 [Serratia sp. FDAARGOS_506]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT114420 NZ_CP033831:1576631-1576891 [Serratia sp. FDAARGOS_506]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAGCAAGCCCTCGCAGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAGCAGCAAAACGTCATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D971