Detailed information of TA system TA114418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 734757..735229
• Replicon: chromosome
• Accession: NZ_CP033831
• Organism: Serratia sp. FDAARGOS_506

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D428
• Locus tag: EGY12_RS03765
• Protein ID: WP_049208401.1
• Coordinates: 734757..735032 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EGY12_RS03770
• Protein ID: WP_123892618.1
• Coordinates: 735038..735229 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY12_RS03740	730078..731358	-	1281	WP_049272501.1	polysaccharide deacetylase family protein	-
EGY12_RS03745	731535..732305	-	771	WP_004937535.1	ABC transporter permease	-
EGY12_RS03750	732302..733225	-	924	WP_015379030.1	ABC transporter ATP-binding protein	-
EGY12_RS03755	733436..734092	+	657	WP_123892617.1	carbonate dehydratase	-
EGY12_RS03760	734130..734666	-	537	WP_048234659.1	hypoxanthine phosphoribosyltransferase	-
EGY12_RS03765	734757..735032	-	276	WP_049208401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGY12_RS03770	735038..735229	-	192	WP_123892618.1	stability determinant	Antitoxin
EGY12_RS03775	735335..736987	-	1653	WP_123892619.1	multicopper oxidase CueO	-
EGY12_RS03780	737193..737540	+	348	WP_004937515.1	YacC family pilotin-like protein	-
EGY12_RS03785	737665..738528	+	864	WP_123892620.1	polyamine aminopropyltransferase	-
EGY12_RS03790	738556..739350	+	795	WP_004937510.1	adenosylmethionine decarboxylase	-
EGY12_RS03795	739383..739745	-	363	WP_123892621.1	protein YacL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10410.13 Da
• Isoelectric Point: 6.8785

>T114418 WP_049208401.1 NZ_CP033831:c735032-734757 [Serratia sp. FDAARGOS_506]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Nucleotide

• Length: 276 bp

>T114418 NZ_CP033831:c735032-734757 [Serratia sp. FDAARGOS_506]
ATGTTAACCGTCAAATGGACTGACGAAGCAAAAACGGGTTTATATACGCTGTTGGCTTTTATCGCTGAGCGGAATCCACT
TGCCGCTGAGGCTTTGTTGCAACGCATTGAAGAGTCGGTTATCCCGTTAGCGGAACATCCTTATCTATTCAGGCCAGGCA
GGGTGAACGGGACTCGTGAAATGGTTGTTCATCCTAATTACATTGTGGTTTACCGCGTGCTGGCTGCACATATTGAAATA
GTGAGTGTCTTGCACGCTCGTCAGGAATACCCTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7160.96 Da
• Isoelectric Point: 5.6492

>AT114418 WP_123892618.1 NZ_CP033831:c735229-735038 [Serratia sp. FDAARGOS_506]
MPTKLDPIVSEFETQEQADSYDRWFKSTVESSINSDSPRIPHDEVMAGARHIIEQAKAKRKSA

Nucleotide

• Length: 192 bp

>AT114418 NZ_CP033831:c735229-735038 [Serratia sp. FDAARGOS_506]
ATGCCGACAAAATTGGATCCCATCGTTTCTGAGTTTGAGACTCAAGAGCAGGCTGATAGTTACGATCGTTGGTTCAAAAG
CACCGTGGAATCTTCCATCAATAGCGACTCCCCCCGTATTCCCCATGACGAAGTCATGGCCGGCGCTCGTCACATTATCG
AGCAGGCGAAAGCCAAAAGAAAATCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A5C7D428