Detailed information of TA system TA114417

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 610323..610992
• Replicon: chromosome
• Accession: NZ_CP033831
• Organism: Serratia sp. FDAARGOS_506

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EGY12_RS03155
• Protein ID: WP_049273462.1
• Coordinates: 610323..610745 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: EGY12_RS03160
• Protein ID: WP_019455657.1
• Coordinates: 610726..610992 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY12_RS03135	606256..607989	-	1734	WP_123892540.1	single-stranded-DNA-specific exonuclease RecJ	-
EGY12_RS03140	607996..608712	-	717	WP_123892541.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
EGY12_RS03145	608739..609638	-	900	WP_123895550.1	site-specific tyrosine recombinase XerD	-
EGY12_RS03150	609745..610263	+	519	WP_123892542.1	flavodoxin FldB	-
EGY12_RS03155	610323..610745	-	423	WP_049273462.1	protein YgfX	Toxin
EGY12_RS03160	610726..610992	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
EGY12_RS03165	611313..612305	+	993	WP_123892543.1	tRNA-modifying protein YgfZ	-
EGY12_RS03170	612344..612841	-	498	WP_123892544.1	DUF2165 domain-containing protein	-
EGY12_RS03175	612992..613666	-	675	WP_123892545.1	hemolysin III family protein	-
EGY12_RS03180	613850..614458	+	609	WP_123892546.1	HD domain-containing protein	-
EGY12_RS03185	614491..615417	-	927	WP_123892547.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16464.53 Da
• Isoelectric Point: 10.8114

>T114417 WP_049273462.1 NZ_CP033831:c610745-610323 [Serratia sp. FDAARGOS_506]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGLGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEPE

Nucleotide

• Length: 423 bp

>T114417 NZ_CP033831:c610745-610323 [Serratia sp. FDAARGOS_506]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACTCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCTTGGCCGGAAGGCTTGGGCCCGCTTTGGCTGGTGCTGTTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCAGTGCAGGGCGAGCTGCGGTTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGCTATGGCATGCTGCTGACGCTGCAGCCGACGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCATCTGCGGCAGCTGTTGCTTTATCCGCCGG
CGGGTGACGGCGAACCAGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT114417 WP_019455657.1 NZ_CP033831:c610992-610726 [Serratia sp. FDAARGOS_506]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT114417 NZ_CP033831:c610992-610726 [Serratia sp. FDAARGOS_506]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04