Detailed information of TA system TA114416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 244502..245158
• Replicon: chromosome
• Accession: NZ_CP033831
• Organism: Serratia sp. FDAARGOS_506

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EGY12_RS01475
• Protein ID: WP_123892349.1
• Coordinates: 244502..244891 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A542BX45
• Locus tag: EGY12_RS01480
• Protein ID: WP_049204860.1
• Coordinates: 244895..245158 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY12_RS01460	240969..242399	+	1431	WP_172962888.1	multidrug transporter subunit MdtD	-
EGY12_RS01465	242396..243778	+	1383	WP_049202687.1	two-component system sensor histidine kinase BaeS	-
EGY12_RS01470	243778..244494	+	717	WP_123892348.1	two-component system response regulator BaeR	-
EGY12_RS01475	244502..244891	-	390	WP_123892349.1	type II toxin-antitoxin system VapC family toxin	Toxin
EGY12_RS01480	244895..245158	-	264	WP_049204860.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
EGY12_RS01485	245496..245834	+	339	WP_123892350.1	YegP family protein	-
EGY12_RS01490	246136..247488	+	1353	WP_123892351.1	tRNA 5-hydroxyuridine modification protein YegQ	-
EGY12_RS01495	247956..248861	+	906	WP_049202693.1	lipid kinase YegS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14296.56 Da
• Isoelectric Point: 7.8786

>T114416 WP_123892349.1 NZ_CP033831:c244891-244502 [Serratia sp. FDAARGOS_506]
MYMFDTNTVSHLFRQHPQVLSIMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T114416 NZ_CP033831:c244891-244502 [Serratia sp. FDAARGOS_506]
ATGTACATGTTTGATACCAATACCGTCAGCCACCTGTTTCGGCAGCATCCGCAGGTGCTAAGCATCATGGAAAAGCTTCC
GCCTTCTGCCGTGTGCATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTCGCTAAGCGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGTGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10076.34 Da
• Isoelectric Point: 4.6820

>AT114416 WP_049204860.1 NZ_CP033831:c245158-244895 [Serratia sp. FDAARGOS_506]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVAER
DPFSEEE

Nucleotide

• Length: 264 bp

>AT114416 NZ_CP033831:c245158-244895 [Serratia sp. FDAARGOS_506]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGTAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTGTATATCCGTCGCGATCGGGAGGGAAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCAGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGAGCGC
GATCCTTTCTCAGAGGAAGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A542BX45