Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3922691..3923348 Replicon chromosome
Accession NZ_CP033824
Organism Klebsiella sp. FDAARGOS_511

Toxin (Protein)


Gene name cptA Uniprot ID H3N294
Locus tag EGY08_RS19990 Protein ID WP_004124948.1
Coordinates 3922938..3923348 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag EGY08_RS19985 Protein ID WP_004124953.1
Coordinates 3922691..3922957 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY08_RS19970 3917946..3918371 - 426 WP_004124962.1 PTS sugar transporter subunit IIA -
EGY08_RS19975 3918492..3921290 - 2799 WP_123828836.1 transcriptional regulator DagR -
EGY08_RS19980 3921463..3922446 - 984 WP_004124956.1 tRNA-modifying protein YgfZ -
EGY08_RS19985 3922691..3922957 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
EGY08_RS19990 3922938..3923348 + 411 WP_004124948.1 protein YgfX Toxin
EGY08_RS19995 3923357..3923878 - 522 WP_004124946.1 flavodoxin FldB -
EGY08_RS20000 3924000..3924896 + 897 WP_004124942.1 site-specific tyrosine recombinase XerD -
EGY08_RS20005 3924919..3925632 + 714 WP_123828837.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EGY08_RS20010 3925638..3927371 + 1734 WP_004124937.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16089.88 Da        Isoelectric Point: 10.9455

>T114407 WP_004124948.1 NZ_CP033824:3922938-3923348 [Klebsiella sp. FDAARGOS_511]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

>T114407 NZ_CP033824:3922938-3923348 [Klebsiella sp. FDAARGOS_511]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGCGCGCAGTGGTTCTCACTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTATTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATATTGCTGTCGCTGGTAGTGTTCGACTGCG
TACGCAGCCAGCGGCGGATCCACGCCCGTCAGGGTGAAATAAAGCTGCTGATCGACTCGCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACGCCGTGGGTAATCAACAGCGGCATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGTAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGCGACCTGCGTCGGCTAGTGTTACAGAAACCGA
CGCAAGAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT114407 WP_004124953.1 NZ_CP033824:3922691-3922957 [Klebsiella sp. FDAARGOS_511]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT114407 NZ_CP033824:3922691-3922957 [Klebsiella sp. FDAARGOS_511]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGTCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTAAGCGATGGCGATAAGGCGTTATTCATCCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCTGAACTGCAGCGGATGGTAAAATTAATTCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3N294

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References