Detailed information of TA system TA114406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1742963..1743782
• Replicon: chromosome
• Accession: NZ_CP033824
• Organism: Klebsiella sp. FDAARGOS_511

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: -
• Locus tag: EGY08_RS09430
• Protein ID: WP_004129235.1
• Coordinates: 1743525..1743782 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A2J4V3L3
• Locus tag: EGY08_RS09425
• Protein ID: WP_049115078.1
• Coordinates: 1742963..1743514 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY08_RS09405	1738596..1739360	+	765	WP_123828438.1	SDR family oxidoreductase	-
EGY08_RS09410	1739409..1739828	+	420	WP_049115076.1	RbsD/FucU family protein	-
EGY08_RS09415	1739872..1740921	-	1050	WP_123828439.1	LacI family transcriptional regulator	-
EGY08_RS09420	1741317..1742945	-	1629	WP_112165897.1	SAM-dependent methyltransferase	-
EGY08_RS09425	1742963..1743514	-	552	WP_049115078.1	N-acetyltransferase	Antitoxin
EGY08_RS09430	1743525..1743782	-	258	WP_004129235.1	YjhX family toxin	Toxin
EGY08_RS09435	1744366..1745550	+	1185	WP_004129234.1	mannonate dehydratase	-
EGY08_RS09440	1745627..1747102	+	1476	WP_112165899.1	fructuronate reductase	-
EGY08_RS09445	1747240..1748016	+	777	WP_004129229.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T114406 WP_004129235.1 NZ_CP033824:c1743782-1743525 [Klebsiella sp. FDAARGOS_511]
MNLSRQEQRTLHVLAKGGRIAHVRDTSGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T114406 NZ_CP033824:c1743782-1743525 [Klebsiella sp. FDAARGOS_511]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACGTTCGCGATACATC
AGGCCGCGTCACCTCCGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAACAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20051.94 Da
• Isoelectric Point: 7.5404

>AT114406 WP_049115078.1 NZ_CP033824:c1743514-1742963 [Klebsiella sp. FDAARGOS_511]
MTNHSFTFHVASEGDTDDILNVETRAFGYSKEARLVASLLNDESASPTLSLLARHNGKAVGHILFTRAMFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGALIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQRLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT114406 NZ_CP033824:c1743514-1742963 [Klebsiella sp. FDAARGOS_511]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCAATGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCTCTTTGCTCAACGATGAGAGTGCCAGCCCGACGTTATCGCTGCTGGCCA
GGCATAACGGAAAGGCGGTTGGGCATATTTTATTCACCCGGGCGATGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGCGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCCATGGGAAGCCAGACGGTATTTGTTCTGGGCCACGCCACTTACTACCCCAGGCACGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGAGGCGCATAAAGCCTGCTGGATGCTACAGCGGCTTTCGTCT
CAGCCGCTGGGGCGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2J4V3L3