Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1497686..1498305 Replicon chromosome
Accession NZ_CP033824
Organism Klebsiella sp. FDAARGOS_511

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag EGY08_RS08275 Protein ID WP_004099646.1
Coordinates 1498087..1498305 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag EGY08_RS08270 Protein ID WP_004129911.1
Coordinates 1497686..1498060 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY08_RS08260 1492856..1494049 + 1194 WP_004129915.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EGY08_RS08265 1494072..1497218 + 3147 WP_004129913.1 multidrug efflux RND transporter permease subunit -
EGY08_RS08270 1497686..1498060 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
EGY08_RS08275 1498087..1498305 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
EGY08_RS08280 1498467..1499033 + 567 WP_123828394.1 maltose O-acetyltransferase -
EGY08_RS08285 1499160..1499630 + 471 WP_004129906.1 YlaC family protein -
EGY08_RS08290 1499605..1501059 - 1455 WP_123828395.1 PLP-dependent aminotransferase family protein -
EGY08_RS08295 1501160..1501858 + 699 WP_123828396.1 GNAT family N-acetyltransferase -
EGY08_RS08300 1501855..1501995 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EGY08_RS08305 1501995..1502258 - 264 WP_004129897.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T114405 WP_004099646.1 NZ_CP033824:1498087-1498305 [Klebsiella sp. FDAARGOS_511]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T114405 NZ_CP033824:1498087-1498305 [Klebsiella sp. FDAARGOS_511]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCAGCGGCCGACCATCGTCTTGCTGAGC
TGACGATGAATAAACTGTATGACAAGATCCCACCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT114405 WP_004129911.1 NZ_CP033824:1497686-1498060 [Klebsiella sp. FDAARGOS_511]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT114405 NZ_CP033824:1497686-1498060 [Klebsiella sp. FDAARGOS_511]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGACCCAACTTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCGCTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGATTACTCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGTGCGGATCTGCAGAAATGGCGCAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References