Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 5052870..5053489 Replicon chromosome
Accession NZ_CP033817
Organism Klebsiella aerogenes strain FDAARGOS_513

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag EGY11_RS24815 Protein ID WP_015367918.1
Coordinates 5053271..5053489 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag EGY11_RS24810 Protein ID WP_015367917.1
Coordinates 5052870..5053244 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY11_RS24800 5048029..5049228 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EGY11_RS24805 5049251..5052397 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit -
EGY11_RS24810 5052870..5053244 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
EGY11_RS24815 5053271..5053489 + 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
EGY11_RS24820 5053621..5054184 + 564 WP_015367919.1 maltose O-acetyltransferase -
EGY11_RS24830 5054310..5054774 + 465 WP_015367920.1 YlaC family protein -
EGY11_RS24835 5054749..5056203 - 1455 WP_015367921.1 PLP-dependent aminotransferase family protein -
EGY11_RS24840 5056306..5057016 + 711 WP_015367922.1 GNAT family N-acetyltransferase -
EGY11_RS24845 5057013..5057153 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EGY11_RS24850 5057156..5057416 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5052870..5063472 10602


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T114401 WP_015367918.1 NZ_CP033817:5053271-5053489 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T114401 NZ_CP033817:5053271-5053489 [Klebsiella aerogenes]
ATGTCTGGTAAACCATTAACTAAAACAGACTATTTGATGCGTTTACGCCGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAGAATAAATATGAACTTTCCGACAATGAATTGGCGGTATTTTACTCAGCAGCCGACCATCGTCTTGCTGAAT
TGACCATGAATAAGCTATACGACAAAATCCCAACTTCAGTATGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT114401 WP_015367917.1 NZ_CP033817:5052870-5053244 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT114401 NZ_CP033817:5052870-5053244 [Klebsiella aerogenes]
ATGGACGAGTACTCGCCAAAAAGACATGATATCGCGCAGCTAAGATTTCTCTGCGAAACGTTGTATCATGACTGCCTTGC
AAACCTGGAAGAAAGCAACCGCGGCTGGGTTAACGATCCCACCTCGGCGGTGAATCTTCAATTAAATGAATTGATCGAGC
ACATAGCAACTTACGCGCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATTTCTCAGCTTGATGAATACCTG
GATGACACTTTTATGCTGTTCAGTAGCTATGGCATAAACACAAGCGATCTCCAAAAATGGCGCAAATCCGGCAATCGGTT
ATTCCGATGCTTTGTGAACGCCAGCCGGGAGAACCCGGCAAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References