Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3775363..3776102 Replicon chromosome
Accession NZ_CP033817
Organism Klebsiella aerogenes strain FDAARGOS_513

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag EGY11_RS18550 Protein ID WP_032705770.1
Coordinates 3775617..3776102 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag EGY11_RS18545 Protein ID WP_015366659.1
Coordinates 3775363..3775629 (+) Length 89 a.a.

Genomic Context

EGY11_RS18525EGY11_RS18530EGY11_RS18535EGY11_RS18545EGY11_RS18550EGY11_RS18555EGY11_RS18560EGY11_RS18570EGY11_RS18540EGY11_RS18565
Location: 3771656..3772273 (618 bp)
Type: Others
Protein ID: WP_032705773.1
Location: 3772369..3772866 (498 bp)
Type: Others
Protein ID: WP_015366656.1
Location: 3773267..3773800 (534 bp)
Type: Others
Protein ID: WP_100280375.1
Location: 3775363..3775629 (267 bp)
Type: Antitoxin
Protein ID: WP_015366659.1
Location: 3775617..3776102 (486 bp)
Type: Toxin
Protein ID: WP_032705770.1
Location: 3776174..3777790 (1617 bp)
Type: Others
Protein ID: WP_015366662.1
Location: 3777909..3779009 (1101 bp)
Type: Others
Protein ID: WP_015366663.1
Location: 3779485..3780555 (1071 bp)
Type: Others
Protein ID: WP_015366664.1
Location: 3773855..3775090 (1236 bp)
Type: Others
Protein ID: WP_015366658.1
Location: 3779066..3779224 (159 bp)
Type: Others
Protein ID: WP_002903230.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EGY11_RS185253771656..3772273+618WP_032705773.1response regulator transcription factor-
EGY11_RS185303772369..3772866+498WP_015366656.1heme-binding protein-
EGY11_RS185353773267..3773800+534WP_100280375.1N-acetyltransferase-
EGY11_RS185403773855..3775090-1236WP_015366658.1MFS transporter-
EGY11_RS185453775363..3775629+267WP_015366659.1DUF1778 domain-containing proteinAntitoxin
EGY11_RS185503775617..3776102+486WP_032705770.1GNAT family N-acetyltransferaseToxin
EGY11_RS185553776174..3777790+1617WP_015366662.1FAD-NAD(P)-binding protein-
EGY11_RS185603777909..3779009+1101WP_015366663.1NADH:flavin oxidoreductase/NADH oxidase-
EGY11_RS185653779066..3779224-159WP_002903230.1YqaE/Pmp3 family membrane protein-
EGY11_RS185703779485..3780555+1071WP_015366664.1mannonate dehydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T114400 WP_032705770.1 NZ_CP033817:3775617-3776102 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T114400 NZ_CP033817:3775617-3776102 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCACAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACTCGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTTTCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTGTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTACGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCAACCACCCAGGAACGCACTCTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10075.52 Da        Isoelectric Point: 4.6558

>AT114400 WP_015366659.1 NZ_CP033817:3775363-3775629 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANSALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT114400 NZ_CP033817:3775363-3775629 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCTTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACTCCGCTCTCGATAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References