Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 712284..712896 Replicon chromosome
Accession NZ_CP033815
Organism Streptococcus pyogenes strain FDAARGOS_514

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag EGX80_RS03900 Protein ID WP_002982731.1
Coordinates 712561..712896 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5S4TJ53
Locus tag EGX80_RS03895 Protein ID WP_011055007.1
Coordinates 712284..712571 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX80_RS03870 707476..708459 - 984 WP_011055003.1 tagatose-bisphosphate aldolase -
EGX80_RS03875 708463..709392 - 930 WP_011055004.1 tagatose-6-phosphate kinase -
EGX80_RS03880 709438..709953 - 516 WP_011055005.1 galactose-6-phosphate isomerase subunit LacB -
EGX80_RS03885 709988..710416 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
EGX80_RS03890 710861..711634 + 774 WP_011055006.1 DeoR/GlpR family DNA-binding transcription regulator -
EGX80_RS03895 712284..712571 + 288 WP_011055007.1 hypothetical protein Antitoxin
EGX80_RS03900 712561..712896 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX80_RS03905 713053..713235 + 183 WP_011106898.1 integrase -
EGX80_RS03910 713597..714034 + 438 WP_079992504.1 site-specific integrase -
EGX80_RS03920 714166..714558 - 393 WP_002982716.1 30S ribosomal protein S9 -
EGX80_RS03925 714579..715025 - 447 WP_002982710.1 50S ribosomal protein L13 -
EGX80_RS03930 715243..715449 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
EGX80_RS03935 715446..716144 - 699 WP_011055008.1 hypothetical protein -
EGX80_RS03940 716271..717131 - 861 WP_011055009.1 DegV family protein -
EGX80_RS03945 717228..717746 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T114389 WP_002982731.1 NZ_CP033815:712561-712896 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T114389 NZ_CP033815:712561-712896 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 5.2318

>AT114389 WP_011055007.1 NZ_CP033815:712284-712571 [Streptococcus pyogenes]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT114389 NZ_CP033815:712284-712571 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAACGGTTACCTTTCAAGCTAATAAAGAACTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A5S4TJ53

References