Detailed information of TA system TA114389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 712284..712896
• Replicon: chromosome
• Accession: NZ_CP033815
• Organism: Streptococcus pyogenes strain FDAARGOS_514

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: EGX80_RS03900
• Protein ID: WP_002982731.1
• Coordinates: 712561..712896 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A5S4TJ53
• Locus tag: EGX80_RS03895
• Protein ID: WP_011055007.1
• Coordinates: 712284..712571 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX80_RS03870	707476..708459	-	984	WP_011055003.1	tagatose-bisphosphate aldolase	-
EGX80_RS03875	708463..709392	-	930	WP_011055004.1	tagatose-6-phosphate kinase	-
EGX80_RS03880	709438..709953	-	516	WP_011055005.1	galactose-6-phosphate isomerase subunit LacB	-
EGX80_RS03885	709988..710416	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
EGX80_RS03890	710861..711634	+	774	WP_011055006.1	DeoR/GlpR family DNA-binding transcription regulator	-
EGX80_RS03895	712284..712571	+	288	WP_011055007.1	hypothetical protein	Antitoxin
EGX80_RS03900	712561..712896	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGX80_RS03905	713053..713235	+	183	WP_011106898.1	integrase	-
EGX80_RS03910	713597..714034	+	438	WP_079992504.1	site-specific integrase	-
EGX80_RS03920	714166..714558	-	393	WP_002982716.1	30S ribosomal protein S9	-
EGX80_RS03925	714579..715025	-	447	WP_002982710.1	50S ribosomal protein L13	-
EGX80_RS03930	715243..715449	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
EGX80_RS03935	715446..716144	-	699	WP_011055008.1	hypothetical protein	-
EGX80_RS03940	716271..717131	-	861	WP_011055009.1	DegV family protein	-
EGX80_RS03945	717228..717746	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T114389 WP_002982731.1 NZ_CP033815:712561-712896 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T114389 NZ_CP033815:712561-712896 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10964.59 Da
• Isoelectric Point: 5.2318

>AT114389 WP_011055007.1 NZ_CP033815:712284-712571 [Streptococcus pyogenes]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT114389 NZ_CP033815:712284-712571 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAACGGTTACCTTTCAAGCTAATAAAGAACTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A5S4TJ53