Detailed information of TA system TA114388

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2336199..2336970
• Replicon: chromosome
• Accession: NZ_CP033814
• Organism: Staphylococcus haemolyticus strain FDAARGOS_517

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: EGX85_RS11715
• Protein ID: WP_011275410.1
• Coordinates: 2336821..2336970 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: EGX85_RS11710
• Protein ID: WP_011275409.1
• Coordinates: 2336199..2336798 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX85_RS11690	2332082..2333536	+	1455	Protein_2208	ABC transporter substrate-binding protein/permease	-
EGX85_RS11695	2333529..2334251	+	723	WP_016931345.1	amino acid ABC transporter ATP-binding protein	-
EGX85_RS11700	2334429..2335556	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
EGX85_RS11705	2335557..2336027	+	471	WP_016931343.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
EGX85_RS11710	2336199..2336798	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
EGX85_RS11715	2336821..2336970	+	150	WP_011275410.1	hypothetical protein	Toxin
EGX85_RS11720	2337181..2337576	+	396	WP_011275411.1	hypothetical protein	-
EGX85_RS11725	2337783..2339168	+	1386	WP_037571293.1	class II fumarate hydratase	-
EGX85_RS11730	2339234..2340058	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
EGX85_RS11735	2340246..2341355	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T114388 WP_011275410.1 NZ_CP033814:2336821-2336970 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T114388 NZ_CP033814:2336821-2336970 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT114388 WP_011275409.1 NZ_CP033814:2336199-2336798 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT114388 NZ_CP033814:2336199-2336798 [Staphylococcus haemolyticus]
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAATAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTTTAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCTTACTATGAAGCATTAGGTGTA
CCTGCTAGTCAAATTTATCCAATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCATCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAGGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2