Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2189308..2189840 Replicon chromosome
Accession NZ_CP033814
Organism Staphylococcus haemolyticus strain FDAARGOS_517

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag EGX85_RS10885 Protein ID WP_011275272.1
Coordinates 2189475..2189840 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag EGX85_RS10880 Protein ID WP_011275271.1
Coordinates 2189308..2189478 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX85_RS10855 2185094..2185573 + 480 WP_011275266.1 PH domain-containing protein -
EGX85_RS10860 2185566..2187089 + 1524 WP_016931363.1 PH domain-containing protein -
EGX85_RS10865 2187082..2187609 + 528 WP_033080076.1 PH domain-containing protein -
EGX85_RS10870 2187619..2187978 + 360 WP_011275269.1 holo-ACP synthase -
EGX85_RS10875 2188074..2189222 + 1149 WP_016931365.1 alanine racemase -
EGX85_RS10880 2189308..2189478 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EGX85_RS10885 2189475..2189840 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EGX85_RS10890 2190148..2191149 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
EGX85_RS10895 2191248..2191574 + 327 WP_011275274.1 anti-sigma factor antagonist -
EGX85_RS10900 2191576..2192055 + 480 WP_011275275.1 anti-sigma B factor RsbW -
EGX85_RS10905 2192030..2192800 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T114387 WP_011275272.1 NZ_CP033814:2189475-2189840 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T114387 NZ_CP033814:2189475-2189840 [Staphylococcus haemolyticus]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTGTCACCAGTACAGGGCTCAGAACAAGGGGGAGTCAGACCTGTAGT
TATCATTCAAAACGATACTGGTAACAAATATAGTCCTACCGTAATCGTTGCTGCGATTACGGGAAGGATTAATAAAGCGA
AAATACCCACACATGTTGAAATCGAGAAAAAGAAATACAGACTTGATAAAGATTCAGTTATTCTACTCGAGCAAATTAGA
ACATTAGATAAAAAACGACTAAAAGAAAAATTAACATATCTATCTGATGAGAAAATGCAAGAAGTGGATGAAGCGTTAGA
CATTAGTCTAGGATTGCATGATGAAGTTAAAACGCAAAACACATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT114387 WP_011275271.1 NZ_CP033814:2189308-2189478 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT114387 NZ_CP033814:2189308-2189478 [Staphylococcus haemolyticus]
ATGCTTACTTTCAATCAAAATAGAAGTCACAGTCTTGAACAATCTTTAAAAGAAGGCTATGCACAAATGGCCGAATTAAA
TCTCTCCCTAGCGACAGAAGCTTTTCCTCTAGAATGCGAAGCTTGTGATTGCAACGAAACGTACCTTATTTCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References