Detailed information of TA system TA114386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2176401..2176912
• Replicon: chromosome
• Accession: NZ_CP033814
• Organism: Staphylococcus haemolyticus strain FDAARGOS_517

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: EGX85_RS10820
• Protein ID: WP_011275259.1
• Coordinates: 2176706..2176912 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: EGX85_RS10815
• Protein ID: WP_011275258.1
• Coordinates: 2176401..2176694 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX85_RS10795	2171561..2172436	+	876	WP_126116876.1	membrane protein insertase YidC	-
EGX85_RS10800	2172631..2173942	+	1312	Protein_2064	ISL3 family transposase	-
EGX85_RS10805	2173989..2174630	-	642	WP_016931420.1	HD domain-containing protein	-
EGX85_RS10810	2174730..2176214	-	1485	WP_011275257.1	cardiolipin synthase	-
EGX85_RS10815	2176401..2176694	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
EGX85_RS10820	2176706..2176912	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
EGX85_RS10825	2177020..2177157	+	138	WP_011275260.1	hypothetical protein	-
EGX85_RS10830	2177471..2179113	+	1643	Protein_2070	IS1182 family transposase	-
EGX85_RS10835	2179088..2180287	-	1200	WP_011275262.1	rod shape-determining protein RodA	-
EGX85_RS10840	2180705..2181775	+	1071	WP_011275263.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2172631..2178406	5775

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T114386 WP_011275259.1 NZ_CP033814:2176706-2176912 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T114386 NZ_CP033814:2176706-2176912 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT114386 WP_011275258.1 NZ_CP033814:2176401-2176694 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT114386 NZ_CP033814:2176401-2176694 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8