Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 688576..689044 Replicon chromosome
Accession NZ_CP033814
Organism Staphylococcus haemolyticus strain FDAARGOS_517

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag EGX85_RS03530 Protein ID WP_011276326.1
Coordinates 688856..689044 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID Q4L4Q5
Locus tag EGX85_RS03525 Protein ID WP_011276325.1
Coordinates 688576..688833 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX85_RS03490 683752..684477 - 726 WP_033079650.1 type I 3-dehydroquinate dehydratase -
EGX85_RS03495 684640..685062 + 423 WP_016931015.1 organic hydroperoxide resistance protein -
EGX85_RS03500 685325..685816 + 492 WP_049395890.1 GNAT family N-acetyltransferase -
EGX85_RS03505 685948..686565 + 618 WP_033079648.1 LysE/ArgO family amino acid transporter -
EGX85_RS03510 686752..687360 - 609 WP_011276323.1 phosphoglycerate mutase family protein -
EGX85_RS03515 687588..687830 + 243 WP_011276324.1 hypothetical protein -
EGX85_RS03520 687822..688025 - 204 WP_033079647.1 sterile alpha motif-like domain-containing protein -
EGX85_RS03525 688576..688833 + 258 WP_011276325.1 hypothetical protein Antitoxin
EGX85_RS03530 688856..689044 + 189 WP_011276326.1 hypothetical protein Toxin
EGX85_RS03535 689162..689743 + 582 WP_033079646.1 orthopoxovirus protein, PF05708 family -
EGX85_RS03540 689791..690027 - 237 WP_016931008.1 hypothetical protein -
EGX85_RS03545 690197..690943 + 747 WP_033079645.1 membrane lipoprotein lipid attachment site-containing protein -
EGX85_RS03550 691012..691620 - 609 WP_033079644.1 GNAT family N-acetyltransferase -
EGX85_RS03555 691757..692503 + 747 WP_033079643.1 poly-gamma-glutamate hydrolase family protein -
EGX85_RS03560 692579..692866 + 288 WP_033079642.1 hypothetical protein -
EGX85_RS03565 693110..693334 + 225 WP_033079641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T114382 WP_011276326.1 NZ_CP033814:688856-689044 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T114382 NZ_CP033814:688856-689044 [Staphylococcus haemolyticus]
ATGAGTTTGCATTTAACTATATTGTTATGGCTTGGTATCATTTTTGTAATAGCAGCCTCAATTATATTGGGCTTATTACT
TAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGTTTTACCGTAATATTTTATATTTTTGGATTTGCTTTACTCA
TCTACGTATTCATATTTGGTATATTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9914.97 Da        Isoelectric Point: 4.0625

>AT114382 WP_011276325.1 NZ_CP033814:688576-688833 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Download         Length: 258 bp

>AT114382 NZ_CP033814:688576-688833 [Staphylococcus haemolyticus]
ATGAATAATAATAAAATTTTTTGGATAAATATTTTTATGACGCTATTATTTTTGGGTTTCAATATCATTGTCACTTACAA
TGCAGACTTAGATGATTTCTTCTGGCTAATTCCAGGACTGACAATTAGTGGTATCACAATTGTACTAAGCTTAAGTACTG
CGCTCATTTGCAAGAACCTGGTTAGCGAAGTTATTTTTCTAATCAATATTGTTATGCTTTTATACTACATTTATCCTATG
GTATATACATTCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1KAX9

References