Detailed information of TA system TA114381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1213323..1213874
• Replicon: chromosome
• Accession: NZ_CP033810
• Organism: Streptococcus sp. FDAARGOS_520

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7Z6WID7
• Locus tag: EGX96_RS06430
• Protein ID: WP_000285204.1
• Coordinates: 1213323..1213601 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Z6WI90
• Locus tag: EGX96_RS06435
• Protein ID: WP_000246822.1
• Coordinates: 1213602..1213874 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX96_RS06395	1208400..1208786	-	387	WP_000058816.1	hypothetical protein	-
EGX96_RS06400	1208764..1209996	-	1233	WP_000625216.1	replication initiation factor domain-containing protein	-
EGX96_RS06405	1210208..1211866	-	1659	WP_001882899.1	cell division protein FtsK	-
EGX96_RS06410	1211873..1212283	-	411	WP_000216328.1	DUF961 family protein	-
EGX96_RS06415	1212306..1212620	-	315	WP_000406626.1	hypothetical protein	-
EGX96_RS06420	1212734..1212961	-	228	WP_001105756.1	hypothetical protein	-
EGX96_RS06425	1212958..1213194	-	237	WP_001000876.1	hypothetical protein	-
EGX96_RS06430	1213323..1213601	-	279	WP_000285204.1	type II toxin-antitoxin system YafQ family toxin	Toxin
EGX96_RS06435	1213602..1213874	-	273	WP_000246822.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EGX96_RS06440	1214555..1214917	+	363	WP_000483806.1	helix-turn-helix domain-containing protein	-
EGX96_RS06445	1214924..1215775	+	852	WP_172581992.1	ImmA/IrrE family metallo-endopeptidase	-
EGX96_RS06450	1215795..1216157	-	363	WP_000722890.1	hypothetical protein	-
EGX96_RS06455	1216245..1217795	-	1551	WP_001145976.1	DNA cytosine methyltransferase	-
EGX96_RS06460	1217989..1218450	+	462	WP_000443123.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1159121..1220241	61120

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-79)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10954.81 Da
• Isoelectric Point: 8.0384

>T114381 WP_000285204.1 NZ_CP033810:c1213601-1213323 [Streptococcus sp. FDAARGOS_520]
MYQVKFTSTFKKSYKRIKKRGLEMTLLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Nucleotide

• Length: 279 bp

>T114381 NZ_CP033810:c1213601-1213323 [Streptococcus sp. FDAARGOS_520]
ATGTATCAAGTCAAGTTCACCTCTACTTTTAAAAAGAGCTATAAAAGGATTAAAAAGCGAGGCTTAGAGATGACACTCTT
AGATGAAGTGATTGAAAAACTCCGTCTAGGTCAGACACTCGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGTCATATTAAACCAGATTGGCTCTTGATTTATCTGATTGAAGACGATATTTTGACTTTAACCTTA
GCCGACACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9904.41 Da
• Isoelectric Point: 6.2580

>AT114381 WP_000246822.1 NZ_CP033810:c1213874-1213602 [Streptococcus sp. FDAARGOS_520]
MATVPTQIRIDETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDKTIASYDN
LADLKKALDA

Nucleotide

• Length: 273 bp

>AT114381 NZ_CP033810:c1213874-1213602 [Streptococcus sp. FDAARGOS_520]
ATGGCAACTGTACCAACTCAAATTCGGATTGATGAAACTGTAAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGAAT
GGATATGTCTAGTGCGGTCAATATTTTTCTTCGTCAATGTCTATTGCGTGGTGGACTTCCTTTCACAGTTGAAGTTCCTA
ATTATAGTCAAAAAACCTTAGAAGCTCTGGCAGAAGCTAAACGAATCTCTCGTGATAAAACGATCGCTTCTTATGACAAT
CTAGCAGATTTAAAGAAGGCTCTGGACGCTTAG

Structures

Toxin

• AlphaFold DB: A0A7Z6WID7

Antitoxin

• AlphaFold DB: A0A7Z6WI90