Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2045311..2045923 Replicon chromosome
Accession NZ_CP033809
Organism Streptococcus sp. FDAARGOS_521

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag EGX72_RS10950 Protein ID WP_000384858.1
Coordinates 2045588..2045923 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag EGX72_RS10945 Protein ID WP_000255538.1
Coordinates 2045311..2045598 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX72_RS10895 2040403..2041263 - 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -
EGX72_RS10915 2042106..2042387 - 282 WP_000052406.1 hypothetical protein -
EGX72_RS10920 2042421..2042807 - 387 WP_000259069.1 hypothetical protein -
EGX72_RS10925 2042792..2043472 - 681 WP_001865565.1 hypothetical protein -
EGX72_RS10930 2043445..2044005 - 561 WP_001865562.1 hypothetical protein -
EGX72_RS10935 2044005..2044412 - 408 WP_000749954.1 hypothetical protein -
EGX72_RS10940 2044514..2044804 - 291 WP_000078283.1 WXG100 family type VII secretion target -
EGX72_RS10945 2045311..2045598 + 288 WP_000255538.1 hypothetical protein Antitoxin
EGX72_RS10950 2045588..2045923 + 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX72_RS10955 2046228..2046698 - 471 WP_000130119.1 hypothetical protein -
EGX72_RS10960 2046866..2048122 - 1257 WP_000122833.1 plasmid recombination protein -
EGX72_RS10965 2048438..2048872 - 435 WP_001220479.1 hypothetical protein -
EGX72_RS10970 2048908..2049783 - 876 WP_000770113.1 hypothetical protein -
EGX72_RS10975 2050096..2050725 - 630 WP_123957783.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T114379 WP_000384858.1 NZ_CP033809:2045588-2045923 [Streptococcus sp. FDAARGOS_521]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T114379 NZ_CP033809:2045588-2045923 [Streptococcus sp. FDAARGOS_521]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT114379 WP_000255538.1 NZ_CP033809:2045311-2045598 [Streptococcus sp. FDAARGOS_521]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT114379 NZ_CP033809:2045311-2045598 [Streptococcus sp. FDAARGOS_521]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References