Detailed information of TA system TA114377

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1600777..1601401
• Replicon: chromosome
• Accession: NZ_CP033808
• Organism: Streptococcus sp. FDAARGOS_522

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: EGX70_RS08410
• Protein ID: WP_000253103.1
• Coordinates: 1601054..1601401 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: EGX70_RS08405
• Protein ID: WP_000543070.1
• Coordinates: 1600777..1601064 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX70_RS08365	1595937..1596795	+	859	Protein_1518	primase C-terminal domain-containing protein	-
EGX70_RS08370	1596807..1598201	+	1395	WP_000656430.1	hypothetical protein	-
EGX70_RS08375	1598494..1598751	+	258	WP_001069293.1	hypothetical protein	-
EGX70_RS08380	1598748..1598921	+	174	WP_000694573.1	hypothetical protein	-
EGX70_RS08385	1599079..1599636	+	558	WP_001258765.1	hypothetical protein	-
EGX70_RS08390	1599709..1600197	+	489	WP_000891151.1	hypothetical protein	-
EGX70_RS08395	1600204..1600356	+	153	Protein_1524	DUF1492 domain-containing protein	-
EGX70_RS08400	1600331..1600708	+	378	WP_000038826.1	DUF1492 domain-containing protein	-
EGX70_RS08405	1600777..1601064	+	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
EGX70_RS08410	1601054..1601401	+	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGX70_RS08415	1601885..1602181	+	297	WP_001052249.1	DUF4298 domain-containing protein	-
EGX70_RS08420	1602267..1602806	-	540	WP_123948071.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
EGX70_RS08425	1602945..1605263	+	2319	WP_000883414.1	YhgE/Pip domain-containing protein	-
EGX70_RS08430	1605330..1605686	+	357	WP_000105934.1	DUF1304 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T114377 WP_000253103.1 NZ_CP033808:1601054-1601401 [Streptococcus sp. FDAARGOS_522]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T114377 NZ_CP033808:1601054-1601401 [Streptococcus sp. FDAARGOS_522]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTATCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT114377 WP_000543070.1 NZ_CP033808:1600777-1601064 [Streptococcus sp. FDAARGOS_522]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT114377 NZ_CP033808:1600777-1601064 [Streptococcus sp. FDAARGOS_522]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5