114376

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1306108..1306720 Replicon chromosome
Accession NZ_CP033808
Organism Streptococcus sp. FDAARGOS_522

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag EGX70_RS06640 Protein ID WP_000384858.1
Coordinates 1306385..1306720 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag EGX70_RS06635 Protein ID WP_000255538.1
Coordinates 1306108..1306395 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX70_RS06605 1301577..1301915 + 339 WP_123948022.1 hypothetical protein -
EGX70_RS06610 1301915..1302448 + 534 WP_123948024.1 hypothetical protein -
EGX70_RS06615 1302429..1303220 + 792 WP_123948026.1 cell division protein FtsK -
EGX70_RS06620 1303406..1304152 + 747 WP_123948028.1 Rep protein -
EGX70_RS06625 1304164..1304424 + 261 WP_001196072.1 helix-turn-helix domain-containing protein -
EGX70_RS06630 1304485..1305705 + 1221 WP_123948030.1 tyrosine-type recombinase/integrase -
EGX70_RS06635 1306108..1306395 + 288 WP_000255538.1 hypothetical protein Antitoxin
EGX70_RS06640 1306385..1306720 + 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX70_RS06645 1307025..1307495 - 471 WP_000130119.1 hypothetical protein -
EGX70_RS06650 1307663..1308919 - 1257 WP_000122832.1 plasmid recombination protein -
EGX70_RS06655 1309235..1309669 - 435 WP_001220479.1 hypothetical protein -
EGX70_RS06660 1309705..1310580 - 876 WP_000770113.1 hypothetical protein -
EGX70_RS06665 1310893..1311522 - 630 WP_123948032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T114376 WP_000384858.1 NZ_CP033808:1306385-1306720 [Streptococcus sp. FDAARGOS_522]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T114376 NZ_CP033808:1306385-1306720 [Streptococcus sp. FDAARGOS_522]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT114376 WP_000255538.1 NZ_CP033808:1306108-1306395 [Streptococcus sp. FDAARGOS_522]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT114376 NZ_CP033808:1306108-1306395 [Streptococcus sp. FDAARGOS_522]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References