Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 85991..86517 Replicon plasmid unnamed3
Accession NZ_CP033799
Organism Enterobacter roggenkampii strain FDAARGOS_523

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EGY04_RS01415 Protein ID WP_000323025.1
Coordinates 86230..86517 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag EGY04_RS01410 Protein ID WP_004196370.1
Coordinates 85991..86230 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY04_RS01380 81328..81520 - 193 Protein_82 MFS transporter -
EGY04_RS01385 81550..82527 + 978 WP_004196334.1 chromate resistance protein -
EGY04_RS01390 82484..83860 + 1377 WP_004196363.1 chromate efflux transporter -
EGY04_RS01395 83891..84580 - 690 WP_004196322.1 hypothetical protein -
EGY04_RS01400 84594..85331 - 738 WP_008460272.1 HupE/UreJ family protein -
EGY04_RS01405 85375..85740 - 366 WP_009651956.1 hypothetical protein -
EGY04_RS01410 85991..86230 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EGY04_RS01415 86230..86517 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EGY04_RS01420 86589..86747 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
EGY04_RS01425 87626..87940 + 315 WP_023338051.1 hypothetical protein -
EGY04_RS01430 88000..88461 + 462 WP_048974901.1 hypothetical protein -
EGY04_RS01435 88551..88751 + 201 WP_031494497.1 hypothetical protein -
EGY04_RS01440 88792..89583 + 792 WP_032663722.1 N-6 DNA methylase -
EGY04_RS01445 89626..89961 + 336 WP_023345479.1 hypothetical protein -
EGY04_RS01450 90651..90944 + 294 WP_032663725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..130817 130817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 12322.73 Da        Isoelectric Point: 12.7777

>T114375 WP_000323025.1 NZ_CP033799:86230-86517 [Enterobacter roggenkampii]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Download         Length: 288 bp

>T114375 NZ_CP033799:86230-86517 [Enterobacter roggenkampii]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 10271.94 Da        Isoelectric Point: 12.6975

>AT114375 WP_004196370.1 NZ_CP033799:85991-86230 [Enterobacter roggenkampii]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 240 bp

>AT114375 NZ_CP033799:85991-86230 [Enterobacter roggenkampii]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References