114371

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1646751..1647726 Replicon chromosome
Accession NZ_CP033795
Organism Bacillus sp. FDAARGOS_527

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag EGX95_RS10845 Protein ID WP_002027714.1
Coordinates 1646751..1647488 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag EGX95_RS10850 Protein ID WP_000588712.1
Coordinates 1647601..1647726 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX95_RS10820 1641826..1642536 + 711 WP_000787481.1 class I SAM-dependent methyltransferase -
EGX95_RS10825 1642656..1643063 + 408 WP_000072484.1 VOC family protein -
EGX95_RS30365 1643169..1643261 + 93 Protein_1692 methyltransferase -
EGX95_RS10830 1643383..1645068 - 1686 WP_002027713.1 alpha-keto acid decarboxylase family protein -
EGX95_RS10835 1645175..1645657 + 483 WP_000191904.1 MarR family winged helix-turn-helix transcriptional regulator -
EGX95_RS10840 1645825..1646562 + 738 WP_000594123.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
EGX95_RS10845 1646751..1647488 + 738 WP_002027714.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
EGX95_RS10850 1647601..1647726 + 126 WP_000588712.1 hypothetical protein Antitoxin
EGX95_RS30370 1647802..1647978 + 177 WP_000852618.1 hypothetical protein -
EGX95_RS10855 1648122..1649591 + 1470 WP_000287521.1 beta-Ala-His dipeptidase -
EGX95_RS10860 1649668..1650039 - 372 WP_000670600.1 DUF5065 family protein -
EGX95_RS10865 1650182..1650775 + 594 WP_000265892.1 SGNH/GDSL hydrolase family protein -
EGX95_RS10870 1650997..1651530 + 534 WP_000438318.1 sigma-70 family RNA polymerase sigma factor -
EGX95_RS10875 1651520..1652347 + 828 WP_001060779.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T114371 WP_002027714.1 NZ_CP033795:1646751-1647488 [Bacillus sp. FDAARGOS_527]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T114371 NZ_CP033795:1646751-1647488 [Bacillus sp. FDAARGOS_527]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAATACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACATCAATCATTCAAAATGTCAATCCAGTAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGTATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT114371 WP_000588712.1 NZ_CP033795:1647601-1647726 [Bacillus sp. FDAARGOS_527]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT114371 NZ_CP033795:1647601-1647726 [Bacillus sp. FDAARGOS_527]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M9H7T3

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References