Detailed information of TA system TA114338

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2492116..2492921
• Replicon: chromosome
• Accession: NZ_CP033782
• Organism: Staphylococcus epidermidis strain FDAARGOS_529

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: EGX64_RS12365
• Protein ID: WP_020361957.1
• Coordinates: 2492116..2492298 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A829M6U1
• Locus tag: EGX64_RS12370
• Protein ID: WP_020364054.1
• Coordinates: 2492322..2492921 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX64_RS12345	2488028..2488852	+	825	WP_002457882.1	RluA family pseudouridine synthase	-
EGX64_RS12350	2489026..2489508	-	483	Protein_2295	transposase	-
EGX64_RS12355	2489983..2491368	-	1386	WP_020361955.1	class II fumarate hydratase	-
EGX64_RS12360	2491560..2491964	-	405	WP_070846328.1	hypothetical protein	-
EGX64_RS12365	2492116..2492298	-	183	WP_020361957.1	hypothetical protein	Toxin
EGX64_RS12370	2492322..2492921	-	600	WP_020364054.1	glucosamine-6-phosphate isomerase	Antitoxin
EGX64_RS12375	2493079..2493549	-	471	WP_002446764.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
EGX64_RS12380	2493546..2494676	-	1131	WP_002476052.1	tRNA epoxyqueuosine(34) reductase QueG	-
EGX64_RS12385	2495024..2495746	-	723	WP_002446766.1	amino acid ABC transporter ATP-binding protein	-
EGX64_RS12390	2495739..2497196	-	1458	Protein_2303	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2489026..2489337	311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7053.64 Da
• Isoelectric Point: 4.3016

>T114338 WP_020361957.1 NZ_CP033782:c2492298-2492116 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLSQPHDNEVRSDFKNSK

Nucleotide

• Length: 183 bp

>T114338 NZ_CP033782:c2492298-2492116 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTGACTGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAGATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAGTCAACCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAACAGTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22663.60 Da
• Isoelectric Point: 4.9942

>AT114338 WP_020364054.1 NZ_CP033782:c2492921-2492322 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLGKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDVSVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAVGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT114338 NZ_CP033782:c2492921-2492322 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGGGCAAAGAACATGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGCCAAATTTATTCAATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAGGGAAAACTGACAATGCAAGTCCTTACGATTGACGAAAATGGCAAACTTGACGTTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTCAATGTTATCTTAGATAAAGAAGCGGCTGTAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A829M6U1