Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 104912..105421 Replicon chromosome
Accession NZ_CP033782
Organism Staphylococcus epidermidis strain FDAARGOS_529

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0E1VPY9
Locus tag EGX64_RS00700 Protein ID WP_002447767.1
Coordinates 104912..105121 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A829M395
Locus tag EGX64_RS00705 Protein ID WP_002458700.1
Coordinates 105128..105421 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX64_RS00680 100491..101846 - 1356 WP_002447764.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
EGX64_RS00685 101858..102931 - 1074 WP_002458698.1 D-alanine--D-alanine ligase -
EGX64_RS00690 103322..104533 + 1212 WP_002447766.1 rod shape-determining protein RodA -
EGX64_RS00695 104632..104769 - 138 WP_001829949.1 hypothetical protein -
EGX64_RS00700 104912..105121 - 210 WP_002447767.1 cation transporter Toxin
EGX64_RS00705 105128..105421 - 294 WP_002458700.1 copper-sensing transcriptional repressor CsoR Antitoxin
EGX64_RS00710 105595..107079 + 1485 WP_002447769.1 cardiolipin synthase -
EGX64_RS00715 107261..107914 + 654 WP_002495677.1 HD domain-containing protein -
EGX64_RS00720 108021..108893 - 873 WP_002458703.1 membrane protein insertase YidC -
EGX64_RS00725 108982..109620 - 639 WP_002458704.1 thiamine phosphate synthase -
EGX64_RS00730 109626..110414 - 789 WP_002486939.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(10-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8008.28 Da        Isoelectric Point: 6.4556

>T114337 WP_002447767.1 NZ_CP033782:c105121-104912 [Staphylococcus epidermidis]
MKLKKGLIHVSGIKTTEQEKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDCGFRIL

Download         Length: 210 bp

>T114337 NZ_CP033782:c105121-104912 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATACATGTTTCAGGTATTAAAACAACTGAACAAGAGAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTGGAATTTGACACTCCCGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTGCGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11082.71 Da        Isoelectric Point: 5.5778

>AT114337 WP_002458700.1 NZ_CP033782:c105421-105128 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVAIKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT114337 NZ_CP033782:c105421-105128 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATCAATCGTATGATTGATGACGATGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTATTAAATTACTAGATCATCACATGAAGGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VPY9

Antitoxin

Source ID Structure
AlphaFold DB A0A829M395

References