Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2091323..2091977 Replicon chromosome
Accession NZ_CP033780
Organism Citrobacter koseri strain FDAARGOS_530

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag EGX86_RS10000 Protein ID WP_114848306.1
Coordinates 2091570..2091977 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag EGX86_RS09995 Protein ID WP_112001575.1
Coordinates 2091323..2091589 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX86_RS09970 2086467..2087900 - 1434 WP_012135007.1 6-phospho-beta-glucosidase BglA -
EGX86_RS09975 2088021..2088749 - 729 WP_114848308.1 MurR/RpiR family transcriptional regulator -
EGX86_RS09980 2088802..2089113 + 312 WP_114848307.1 N(4)-acetylcytidine aminohydrolase -
EGX86_RS09985 2089275..2089934 + 660 WP_012135004.1 hemolysin III family protein -
EGX86_RS09990 2090086..2091066 - 981 WP_058668058.1 tRNA-modifying protein YgfZ -
EGX86_RS09995 2091323..2091589 + 267 WP_112001575.1 FAD assembly factor SdhE Antitoxin
EGX86_RS10000 2091570..2091977 + 408 WP_114848306.1 protein YgfX Toxin
EGX86_RS10005 2092075..2092599 - 525 WP_012134999.1 flavodoxin FldB -
EGX86_RS10010 2092703..2093599 + 897 WP_012134998.1 site-specific tyrosine recombinase XerD -
EGX86_RS10015 2093623..2094336 + 714 WP_114848305.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EGX86_RS10020 2094342..2096075 + 1734 WP_114848304.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15916.82 Da        Isoelectric Point: 11.2845

>T114326 WP_114848306.1 NZ_CP033780:2091570-2091977 [Citrobacter koseri]
VVLWQSDLRVSWRAQWLSLLIHGLVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRINTRQGEIKLLMDGRLRWQGQ
DWTIQGPPWMLKTGMMLRLRADSGKRQHLWLAADSMDDAEWRDLRRLMLQQVTQG

Download         Length: 408 bp

>T114326 NZ_CP033780:2091570-2091977 [Citrobacter koseri]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGACAGGGCGAAATTAAATTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGCCCGCCCTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGTCA
GCACTTGTGGCTGGCGGCAGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGTGACGC
AGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10475.95 Da        Isoelectric Point: 4.6872

>AT114326 WP_112001575.1 NZ_CP033780:2091323-2091589 [Citrobacter koseri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKCIFVRLLECDDPDLFNWLMNHGKPGDAELEQMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT114326 NZ_CP033780:2091323-2091589 [Citrobacter koseri]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCCATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGGGATGCAGAACTGGAACAAATGGTGCAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References