Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 589152..589859 Replicon chromosome
Accession NZ_CP033780
Organism Citrobacter koseri strain FDAARGOS_530

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag EGX86_RS02750 Protein ID WP_148084109.1
Coordinates 589152..589484 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag EGX86_RS02755 Protein ID WP_123907366.1
Coordinates 589518..589859 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX86_RS02740 585492..586862 - 1371 WP_049010418.1 tyrosine phenol-lyase -
EGX86_RS02745 587887..588894 - 1008 WP_047041139.1 restriction endonuclease -
EGX86_RS02750 589152..589484 - 333 WP_148084109.1 TA system toxin CbtA family protein Toxin
EGX86_RS02755 589518..589859 - 342 WP_123907366.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EGX86_RS02760 589870..590412 - 543 WP_123907367.1 DNA repair protein RadC -
EGX86_RS02765 590425..590865 - 441 WP_123907368.1 antirestriction protein -
EGX86_RS02770 590896..591717 - 822 WP_123907369.1 DUF945 domain-containing protein -
EGX86_RS02775 591838..592311 - 474 WP_123907370.1 hypothetical protein -
EGX86_RS02780 592383..592835 - 453 WP_000734321.1 hypothetical protein -
EGX86_RS02785 592871..593587 - 717 WP_123907371.1 WYL domain-containing protein -
EGX86_RS02790 593831..594706 - 876 WP_123907372.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 587887..623600 35713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(4-106)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12400.24 Da        Isoelectric Point: 5.6618

>T114324 WP_148084109.1 NZ_CP033780:c589484-589152 [Citrobacter koseri]
MLSTTPQAATLCLSPVAVWQMLLACLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYELVRIDRRGFNWQ
EQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 333 bp

>T114324 NZ_CP033780:c589484-589152 [Citrobacter koseri]
CTGCTGTCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTAGCAGTGTGGCAAATGCTGCTTGCATGCCTGCT
GGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCGATGCCGGTA
TATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGAACTGGTTCGTATTGATCGCAGGGGATTCAACTGGCAA
GAACAGTCCCCATATCTGCGGGCAGTAGATATTCTGCGGGCGCGGCAGGCAACTGGTTTATTGAAAAGAAATCGTATTAG
CGCGGCACAGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12754.29 Da        Isoelectric Point: 6.7482

>AT114324 WP_123907366.1 NZ_CP033780:c589859-589518 [Citrobacter koseri]
MKSTGSESDSFLKWGLNRNVTPFFGARLVQEGNRLHYLADRASISGEFSNAESLKLNEVFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSYGYVYIAVYPTHR

Download         Length: 342 bp

>AT114324 NZ_CP033780:c589859-589518 [Citrobacter koseri]
ATGAAATCTACTGGCTCAGAGAGCGATTCATTTCTCAAGTGGGGGCTGAATCGTAATGTGACGCCTTTCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATCTGGCTGACCGGGCCAGCATTAGCGGTGAATTCAGTAACGCAGAATCTT
TGAAGTTGAATGAAGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGTTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References