Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1481703..1482360 Replicon chromosome
Accession NZ_CP033777
Organism Klebsiella pneumoniae strain FDAARGOS_531

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag EGX99_RS09400 Protein ID WP_002916310.1
Coordinates 1481950..1482360 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag EGX99_RS09395 Protein ID WP_002916312.1
Coordinates 1481703..1481969 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX99_RS09370 1476911..1478344 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
EGX99_RS09375 1478463..1479191 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
EGX99_RS09380 1479241..1479552 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
EGX99_RS09385 1479716..1480375 + 660 WP_002916317.1 hemolysin III family protein -
EGX99_RS09390 1480474..1481457 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
EGX99_RS09395 1481703..1481969 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
EGX99_RS09400 1481950..1482360 + 411 WP_002916310.1 protein YgfX Toxin
EGX99_RS09405 1482367..1482888 - 522 WP_004144730.1 flavodoxin FldB -
EGX99_RS09410 1482989..1483885 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
EGX99_RS09415 1483908..1484621 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EGX99_RS09420 1484627..1486360 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T114311 WP_002916310.1 NZ_CP033777:1481950-1482360 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T114311 NZ_CP033777:1481950-1482360 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT114311 WP_002916312.1 NZ_CP033777:1481703-1481969 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT114311 NZ_CP033777:1481703-1481969 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References