Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 4897033..4897538 Replicon chromosome
Accession NZ_CP033771
Organism Pseudomonas aeruginosa strain FDAARGOS_532

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag EGY18_RS23255 Protein ID WP_003121619.1
Coordinates 4897033..4897314 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EGY18_RS23260 Protein ID WP_003083775.1
Coordinates 4897311..4897538 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY18_RS23230 4892284..4893633 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
EGY18_RS23235 4893682..4894368 + 687 WP_003083762.1 FadR family transcriptional regulator -
EGY18_RS23240 4894469..4895203 + 735 WP_003117208.1 GntR family transcriptional regulator -
EGY18_RS23245 4895407..4895793 + 387 WP_014602345.1 aegerolysin family protein -
EGY18_RS23250 4895825..4896733 - 909 WP_023083551.1 LysR family transcriptional regulator -
EGY18_RS23255 4897033..4897314 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
EGY18_RS23260 4897311..4897538 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EGY18_RS23265 4897714..4898334 - 621 WP_003101226.1 hypothetical protein -
EGY18_RS23270 4898435..4898935 + 501 WP_003101228.1 LEA type 2 family protein -
EGY18_RS23275 4899008..4899349 + 342 WP_003101229.1 alkylphosphonate utilization protein -
EGY18_RS23280 4899431..4900858 - 1428 WP_003083784.1 GABA permease -
EGY18_RS23285 4901027..4902520 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T114301 WP_003121619.1 NZ_CP033771:c4897314-4897033 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T114301 NZ_CP033771:c4897314-4897033 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT114301 WP_003083775.1 NZ_CP033771:c4897538-4897311 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT114301 NZ_CP033771:c4897538-4897311 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References