Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 2759525..2760178 Replicon chromosome
Accession NZ_CP033768
Organism Acinetobacter baumannii strain FDAARGOS_533

Toxin (Protein)


Gene name cptA Uniprot ID A0A009PMF4
Locus tag EGX83_RS13135 Protein ID WP_032058676.1
Coordinates 2759525..2759914 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag EGX83_RS13140 Protein ID WP_001288210.1
Coordinates 2759921..2760178 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX83_RS13115 2755714..2756280 - 567 WP_000651536.1 rhombosortase -
EGX83_RS13120 2756358..2757191 - 834 Protein_2529 hypothetical protein -
EGX83_RS13125 2757243..2758462 + 1220 WP_123793643.1 IS3 family transposase -
EGX83_RS13130 2758501..2758755 - 255 Protein_2531 hypothetical protein -
EGX83_RS13135 2759525..2759914 - 390 WP_032058676.1 membrane protein Toxin
EGX83_RS13140 2759921..2760178 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
EGX83_RS13145 2760366..2761538 + 1173 WP_032058675.1 acyl-CoA dehydrogenase family protein -
EGX83_RS13150 2761587..2763077 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
EGX83_RS13155 2763259..2763636 - 378 WP_001216380.1 50S ribosomal protein L17 -
EGX83_RS13160 2763655..2764662 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15575.86 Da        Isoelectric Point: 10.4637

>T114293 WP_032058676.1 NZ_CP033768:c2759914-2759525 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFIIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLH

Download         Length: 390 bp

>T114293 NZ_CP033768:c2759914-2759525 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTATTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCGGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCCATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT114293 WP_001288210.1 NZ_CP033768:c2760178-2759921 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT114293 NZ_CP033768:c2760178-2759921 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTCCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009PMF4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References