Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1626363..1626975 Replicon chromosome
Accession NZ_CP033767
Organism Streptococcus pyogenes strain FDAARGOS_534

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag EGX78_RS08380 Protein ID WP_002988077.1
Coordinates 1626640..1626975 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag EGX78_RS08375 Protein ID WP_002988079.1
Coordinates 1626363..1626650 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX78_RS08350 1621554..1622537 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
EGX78_RS08355 1622541..1623470 - 930 WP_002988085.1 tagatose-6-phosphate kinase -
EGX78_RS08360 1623516..1624031 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
EGX78_RS08365 1624066..1624494 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
EGX78_RS08370 1624940..1625713 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
EGX78_RS08375 1626363..1626650 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
EGX78_RS08380 1626640..1626975 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX78_RS08385 1627064..1628107 + 1044 Protein_1541 site-specific integrase -
EGX78_RS08390 1628227..1628619 - 393 WP_002982716.1 30S ribosomal protein S9 -
EGX78_RS08395 1628640..1629086 - 447 WP_002982710.1 50S ribosomal protein L13 -
EGX78_RS08400 1629304..1629510 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
EGX78_RS08405 1629507..1630013 - 507 WP_002988070.1 hypothetical protein -
EGX78_RS08410 1630149..1631009 - 861 WP_002982687.1 DegV family protein -
EGX78_RS08415 1631106..1631624 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T114292 WP_002988077.1 NZ_CP033767:1626640-1626975 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T114292 NZ_CP033767:1626640-1626975 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT114292 WP_002988079.1 NZ_CP033767:1626363-1626650 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT114292 NZ_CP033767:1626363-1626650 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References