Detailed information of TA system TA114292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1626363..1626975
• Replicon: chromosome
• Accession: NZ_CP033767
• Organism: Streptococcus pyogenes strain FDAARGOS_534

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q1JJZ2
• Locus tag: EGX78_RS08380
• Protein ID: WP_002988077.1
• Coordinates: 1626640..1626975 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: EGX78_RS08375
• Protein ID: WP_002988079.1
• Coordinates: 1626363..1626650 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGX78_RS08350	1621554..1622537	-	984	WP_002988088.1	tagatose-bisphosphate aldolase	-
EGX78_RS08355	1622541..1623470	-	930	WP_002988085.1	tagatose-6-phosphate kinase	-
EGX78_RS08360	1623516..1624031	-	516	WP_002988082.1	galactose-6-phosphate isomerase subunit LacB	-
EGX78_RS08365	1624066..1624494	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
EGX78_RS08370	1624940..1625713	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
EGX78_RS08375	1626363..1626650	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
EGX78_RS08380	1626640..1626975	+	336	WP_002988077.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGX78_RS08385	1627064..1628107	+	1044	Protein_1541	site-specific integrase	-
EGX78_RS08390	1628227..1628619	-	393	WP_002982716.1	30S ribosomal protein S9	-
EGX78_RS08395	1628640..1629086	-	447	WP_002982710.1	50S ribosomal protein L13	-
EGX78_RS08400	1629304..1629510	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
EGX78_RS08405	1629507..1630013	-	507	WP_002988070.1	hypothetical protein	-
EGX78_RS08410	1630149..1631009	-	861	WP_002982687.1	DegV family protein	-
EGX78_RS08415	1631106..1631624	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13117.83 Da
• Isoelectric Point: 5.2144

>T114292 WP_002988077.1 NZ_CP033767:1626640-1626975 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T114292 NZ_CP033767:1626640-1626975 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT114292 WP_002988079.1 NZ_CP033767:1626363-1626650 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT114292 NZ_CP033767:1626363-1626650 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A660A236

Antitoxin

• AlphaFold DB: A0A4U7GX94