Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4075425..4076260 Replicon chromosome
Accession NZ_CP033762
Organism Escherichia coli strain FDAARGOS_536

Toxin (Protein)


Gene name yeeV Uniprot ID S1PMM7
Locus tag EGX93_RS20805 Protein ID WP_000854720.1
Coordinates 4075425..4075802 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P8X0
Locus tag EGX93_RS20810 Protein ID WP_001539669.1
Coordinates 4075892..4076260 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX93_RS20770 4070693..4072231 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
EGX93_RS20780 4073114..4073440 - 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
EGX93_RS20785 4073437..4073700 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
EGX93_RS20790 4073772..4074638 - 867 WP_001290180.1 DUF4942 domain-containing protein -
EGX93_RS20795 4074731..4074928 - 198 WP_000839238.1 DUF957 domain-containing protein -
EGX93_RS20800 4074940..4075428 - 489 WP_000777672.1 hypothetical protein -
EGX93_RS20805 4075425..4075802 - 378 WP_000854720.1 TA system toxin CbtA family protein Toxin
EGX93_RS20810 4075892..4076260 - 369 WP_001539669.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EGX93_RS20815 4076340..4076561 - 222 WP_000692349.1 DUF987 domain-containing protein -
EGX93_RS20820 4076648..4077124 - 477 WP_001186788.1 RadC family protein -
EGX93_RS20825 4077140..4077625 - 486 WP_016237304.1 antirestriction protein -
EGX93_RS20830 4077680..4078498 - 819 WP_001234642.1 DUF945 domain-containing protein -
EGX93_RS20840 4078598..4078831 - 234 WP_001119719.1 DUF905 family protein -
EGX93_RS20845 4078917..4079321 + 405 WP_001539664.1 IS66 family insertion sequence hypothetical protein -
EGX93_RS20850 4079318..4079665 + 348 WP_000612617.1 IS66 family insertion sequence element accessory protein TnpB -
EGX93_RS20855 4079714..4081252 + 1539 WP_021545098.1 IS66-like element ISEc22 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.02 Da        Isoelectric Point: 7.9087

>T114286 WP_000854720.1 NZ_CP033762:c4075802-4075425 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T114286 NZ_CP033762:c4075802-4075425 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.39 Da        Isoelectric Point: 5.9550

>AT114286 WP_001539669.1 NZ_CP033762:c4076260-4075892 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT114286 NZ_CP033762:c4076260-4075892 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCATGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAAT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FW05

Antitoxin

Source ID Structure
AlphaFold DB A0A829FYK7

References