Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2719294..2720126 Replicon chromosome
Accession NZ_CP033762
Organism Escherichia coli strain FDAARGOS_536

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag EGX93_RS14325 Protein ID WP_000854753.1
Coordinates 2719752..2720126 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag EGX93_RS14320 Protein ID WP_001540478.1
Coordinates 2719294..2719662 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX93_RS14285 2715127..2715807 + 681 WP_001282919.1 WYL domain-containing protein -
EGX93_RS14290 2715955..2716632 + 678 WP_001097301.1 hypothetical protein -
EGX93_RS14295 2716638..2716871 + 234 WP_001278283.1 DUF905 family protein -
EGX93_RS14300 2716961..2717779 + 819 WP_001234682.1 DUF945 domain-containing protein -
EGX93_RS14305 2717870..2718355 + 486 WP_000214398.1 antirestriction protein -
EGX93_RS14310 2718371..2718847 + 477 WP_001313574.1 RadC family protein -
EGX93_RS14315 2718910..2719131 + 222 WP_000692311.1 DUF987 domain-containing protein -
EGX93_RS14320 2719294..2719662 + 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EGX93_RS14325 2719752..2720126 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
EGX93_RS14330 2720123..2720611 + 489 WP_000777545.1 hypothetical protein -
EGX93_RS14335 2720623..2720820 + 198 WP_000839281.1 DUF957 domain-containing protein -
EGX93_RS14340 2720917..2721486 + 570 WP_001560692.1 DUF4942 domain-containing protein -
EGX93_RS25670 2721844..2721999 + 156 WP_000729638.1 hypothetical protein -
EGX93_RS14345 2722810..2723793 + 984 WP_024946586.1 KpsF/GutQ family sugar-phosphate isomerase -
EGX93_RS14350 2723865..2725013 + 1149 WP_000905920.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T114281 WP_000854753.1 NZ_CP033762:2719752-2720126 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T114281 NZ_CP033762:2719752-2720126 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT114281 WP_001540478.1 NZ_CP033762:2719294-2719662 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT114281 NZ_CP033762:2719294-2719662 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References