Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 624844..625315 Replicon chromosome
Accession NZ_CP033762
Organism Escherichia coli strain FDAARGOS_536

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag EGX93_RS03760 Protein ID WP_001303511.1
Coordinates 624844..625122 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag EGX93_RS03765 Protein ID WP_042020325.1
Coordinates 625124..625315 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX93_RS03720 620056..620325 - 270 WP_000003742.1 excisionase -
EGX93_RS03725 620387..622825 - 2439 WP_000102132.1 exonuclease -
EGX93_RS03730 622918..623106 - 189 WP_000199475.1 DUF1482 family protein -
EGX93_RS03735 623103..623291 - 189 WP_000449175.1 cell division inhibitor -
EGX93_RS03740 623795..624061 + 267 WP_012601410.1 hypothetical protein -
EGX93_RS03745 624050..624388 - 339 WP_000394541.1 hypothetical protein -
EGX93_RS03750 624400..624552 - 153 WP_000380313.1 DUF1391 family protein -
EGX93_RS03760 624844..625122 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGX93_RS03765 625124..625315 - 192 WP_042020325.1 hypothetical protein Antitoxin
EGX93_RS03770 625336..625707 - 372 WP_001169687.1 hypothetical protein -
EGX93_RS03775 625805..626107 + 303 WP_001556930.1 transcriptional regulator -
EGX93_RS03780 626104..626529 + 426 WP_032202891.1 Rha family transcriptional regulator -
EGX93_RS03785 626552..627514 + 963 WP_000095673.1 helix-turn-helix domain-containing protein -
EGX93_RS03790 627521..628267 + 747 WP_032202795.1 ATP-binding protein -
EGX93_RS03795 628289..629059 + 771 WP_023352147.1 DUF1627 domain-containing protein -
EGX93_RS03800 629075..629497 + 423 WP_001151130.1 DUF977 family protein -
EGX93_RS03805 629555..629911 + 357 WP_000403782.1 hypothetical protein -
EGX93_RS03810 630007..630189 + 183 WP_001224665.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 618969..707565 88596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T114267 WP_001303511.1 NZ_CP033762:c625122-624844 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T114267 NZ_CP033762:c625122-624844 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7491.52 Da        Isoelectric Point: 8.6828

>AT114267 WP_042020325.1 NZ_CP033762:c625315-625124 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPVIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT114267 NZ_CP033762:c625315-625124 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGTAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure

References