114259

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 106202..106724 Replicon plasmid unnamed2
Accession NZ_CP033758
Organism Klebsiella pneumoniae strain FDAARGOS_566

Toxin (Protein)


Gene name stbE Uniprot ID A0A4R0GPV2
Locus tag EGY03_RS27740 Protein ID WP_032731992.1
Coordinates 106202..106486 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag EGY03_RS27745 Protein ID WP_004187025.1
Coordinates 106476..106724 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY03_RS27725 103545..103922 - 378 Protein_107 transposase -
EGY03_RS27730 104277..105254 + 978 Protein_108 IS630 family transposase -
EGY03_RS27735 105309..105967 - 659 Protein_109 IS1 family transposase -
EGY03_RS27740 106202..106486 - 285 WP_032731992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGY03_RS27745 106476..106724 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
EGY03_RS27750 106969..107892 - 924 WP_032731993.1 IS5 family transposase -
EGY03_RS27755 108116..109714 + 1599 WP_050597293.1 sensor domain-containing diguanylate cyclase -
EGY03_RS27760 110173..111306 + 1134 WP_022651297.1 glutathione-independent formaldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid formA - 1..232752 232752
- inside IScluster/Tn formA - 96203..113896 17693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11017.75 Da        Isoelectric Point: 10.5388

>T114259 WP_032731992.1 NZ_CP033758:c106486-106202 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGIGK
RENDDIYNATLNRN

Download         Length: 285 bp

>T114259 NZ_CP033758:c106486-106202 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCGCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAGCTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATACCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCATAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT114259 WP_004187025.1 NZ_CP033758:c106724-106476 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp

>AT114259 NZ_CP033758:c106724-106476 [Klebsiella pneumoniae]
ATGGCATTTCAGGTTCTGACCACTACAGCAGCTAGCATTACTGAACTTAAACGTGACCCTATGGGTACTTTCCACGCCGG
GGATGGCGCTCCGGTAGCCATTCTTAATCGTAATGAGCCTGCATTCTACTGTGTGCCACCGGCACTCTATGCCCAGTTGA
TGGAGCTTCTGGAAGATGAAGAGCTGGGACGGATGGCTGATGAGCGAAGCGGAGAAAAGGTTATAGAGGTCAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0GPV2

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References