Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-RelB
Location 883672..884185 Replicon chromosome
Accession NZ_CP033754
Organism Acinetobacter baumannii strain FDAARGOS_540

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2L2M0A2
Locus tag EGX84_RS04995 Protein ID WP_000203952.1
Coordinates 883672..883935 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S7WSW9
Locus tag EGX84_RS05000 Protein ID WP_000557943.1
Coordinates 883922..884185 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX84_RS19615 879041..879151 - 111 Protein_843 AAA family ATPase -
EGX84_RS04945 879204..880423 + 1220 WP_087486619.1 IS3-like element ISAba19 family transposase -
EGX84_RS19620 880464..881113 - 650 Protein_845 IS21-like element ISAba8 family helper ATPase IstB -
EGX84_RS04960 881113..882132 - 1020 WP_002124751.1 IS21 family transposase -
EGX84_RS04965 882237..882866 - 630 Protein_847 IS3 family transposase -
EGX84_RS04975 882925..883242 - 318 Protein_848 LysR family transcriptional regulator -
EGX84_RS04985 883376..883474 + 99 Protein_849 IS5/IS1182 family transposase -
EGX84_RS04990 883506..883613 - 108 Protein_850 transposase domain-containing protein -
EGX84_RS04995 883672..883935 - 264 WP_000203952.1 Txe/YoeB family addiction module toxin Toxin
EGX84_RS05000 883922..884185 - 264 WP_000557943.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EGX84_RS05005 884601..887948 + 3348 WP_123785526.1 DEAD/DEAH box helicase -
EGX84_RS05010 888120..888621 - 502 Protein_854 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 874670..898887 24217
- flank IS/Tn - - 888313..888666 353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10664.10 Da        Isoelectric Point: 8.4894

>T114237 WP_000203952.1 NZ_CP033754:c883935-883672 [Acinetobacter baumannii]
MTSRNVEWTENAWDEYIYWQTQDKKILKRINTLIRECQRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISI
IQCRFHY

Download         Length: 264 bp

>T114237 NZ_CP033754:c883935-883672 [Acinetobacter baumannii]
ATGACGAGTCGTAATGTCGAATGGACTGAAAATGCCTGGGATGAATATATCTATTGGCAAACACAGGATAAAAAGATACT
CAAACGTATCAATACCTTAATCAGAGAATGTCAAAGAACACCCTTTGAAGGAACTGGGAAACCAGAACCTTTAAAAGCAA
ATCTTTCAGGATTCTGGAGCCGTAGAATTGATGAGAAGCATAGATTAGTTTATGAAGTGACGGATGAACGAATTTCCATT
ATTCAATGTCGGTTCCATTACTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9841.04 Da        Isoelectric Point: 5.5940

>AT114237 WP_000557943.1 NZ_CP033754:c884185-883922 [Acinetobacter baumannii]
MHVFTYTDARNNLKSVLDKVIDDADVAFITRKEGGHAVVMGQDHYDSLMETLYLLSSPNNTTRLNESIAQLRAGKTKQRE
LIKDDES

Download         Length: 264 bp

>AT114237 NZ_CP033754:c884185-883922 [Acinetobacter baumannii]
ATGCATGTATTTACATATACAGACGCACGTAACAACTTAAAATCTGTTTTAGATAAAGTTATTGATGATGCAGATGTCGC
TTTCATTACAAGAAAAGAAGGCGGTCATGCTGTAGTAATGGGACAAGATCATTACGATAGTTTAATGGAAACGTTGTATC
TCCTTTCATCTCCAAATAATACCACTCGTTTAAACGAATCAATTGCTCAATTACGCGCAGGTAAAACCAAACAAAGAGAG
TTGATTAAAGATGACGAGTCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L2M0A2

Antitoxin

Source ID Structure
AlphaFold DB S7WSW9

References