Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 213935..214588 Replicon chromosome
Accession NZ_CP033754
Organism Acinetobacter baumannii strain FDAARGOS_540

Toxin (Protein)


Gene name cptA Uniprot ID A0A829RKD8
Locus tag EGX84_RS01760 Protein ID WP_002125600.1
Coordinates 213935..214324 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag EGX84_RS01765 Protein ID WP_001288210.1
Coordinates 214331..214588 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGX84_RS01745 209053..211248 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
EGX84_RS01750 211436..212002 - 567 WP_000651536.1 rhombosortase -
EGX84_RS01755 212080..213165 - 1086 WP_000049106.1 hypothetical protein -
EGX84_RS01760 213935..214324 - 390 WP_002125600.1 hypothetical protein Toxin
EGX84_RS01765 214331..214588 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
EGX84_RS01770 214776..215948 + 1173 WP_002125555.1 acyl-CoA dehydrogenase family protein -
EGX84_RS01775 215997..217487 - 1491 WP_002125480.1 NAD(P)/FAD-dependent oxidoreductase -
EGX84_RS01780 217669..218046 - 378 WP_001216380.1 50S ribosomal protein L17 -
EGX84_RS01785 218065..219072 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15662.98 Da        Isoelectric Point: 10.4623

>T114236 WP_002125600.1 NZ_CP033754:c214324-213935 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKIWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T114236 NZ_CP033754:c214324-213935 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT114236 WP_001288210.1 NZ_CP033754:c214588-214331 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT114236 NZ_CP033754:c214588-214331 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829RKD8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References