Detailed information of TA system TA114233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 1992008..1992708
• Replicon: chromosome
• Accession: NZ_CP033750
• Organism: Burkholderia multivorans strain FDAARGOS_547

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A2S9M997
• Locus tag: EGY20_RS23550
• Protein ID: WP_035951940.1
• Coordinates: 1992008..1992385 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: EGY20_RS23555
• Protein ID: WP_054317404.1
• Coordinates: 1992385..1992708 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY20_RS23525	1987549..1987998	+	450	WP_006413500.1	VOC family protein	-
EGY20_RS23530	1988102..1989652	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
EGY20_RS23535	1989649..1989882	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
EGY20_RS23540	1990079..1990996	-	918	WP_012212961.1	spermidine synthase	-
EGY20_RS23545	1991224..1991478	+	255	WP_123790702.1	hypothetical protein	-
EGY20_RS23550	1992008..1992385	+	378	WP_035951940.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EGY20_RS23555	1992385..1992708	+	324	WP_054317404.1	helix-turn-helix domain-containing protein	Antitoxin
EGY20_RS23560	1992731..1993222	-	492	WP_123790703.1	DNA-deoxyinosine glycosylase	-
EGY20_RS23565	1993219..1993833	-	615	WP_059875775.1	chorismate lyase	-
EGY20_RS23570	1993842..1995740	-	1899	WP_105771785.1	molecular chaperone HtpG	-
EGY20_RS23580	1995899..1997359	-	1461	WP_048805885.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13604.61 Da
• Isoelectric Point: 9.5844

>T114233 WP_035951940.1 NZ_CP033750:1992008-1992385 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARRDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T114233 NZ_CP033750:1992008-1992385 [Burkholderia multivorans]
ATGGGTATAAATTCGTCGATGGTTCCATACACTAAACCGCTTTACTGGCTCGGCTCGGCACGCAGGGACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTCGGCTATGCGCTGTATCTGGCCCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGCTTCGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACACCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGGGCCGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11858.78 Da
• Isoelectric Point: 8.0686

>AT114233 WP_054317404.1 NZ_CP033750:1992385-1992708 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT114233 NZ_CP033750:1992385-1992708 [Burkholderia multivorans]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTGGGCATGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCGGCCAAGATCGCGGAGATCATCAAGACCCGCAAATGGACGCAGCAGCACGCGGCGCGGTTGCTCGGCATGA
CGCAACCGAAGCTATCGAATATGCTGCGCGGGCAGTTTCGCGGCGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGGCGCGATGTCCAGATCGTCGTAGGACCGGACCGTCATTCGGAAACCGAAGGACACATCGAGGTCGTGTTCGCTGC
CTGA

Structures

Toxin

• AlphaFold DB: A0A2S9M997