Detailed information of TA system TA114231

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2054604..2055865
• Replicon: chromosome
• Accession: NZ_CP033748
• Organism: Burkholderia multivorans strain FDAARGOS_547

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: EGY20_RS09385
• Protein ID: WP_060144520.1
• Coordinates: 2055287..2055865 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EGY20_RS09380
• Protein ID: WP_123789612.1
• Coordinates: 2054604..2055161 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGY20_RS09355	2049652..2050668	+	1017	WP_006412465.1	AraC family transcriptional regulator	-
EGY20_RS09360	2050797..2051435	+	639	WP_006412473.1	cysteine hydrolase	-
EGY20_RS09365	2051616..2052347	-	732	WP_123789611.1	ribonuclease T2	-
EGY20_RS09370	2052689..2054092	-	1404	WP_105803550.1	hypothetical protein	-
EGY20_RS09380	2054604..2055161	+	558	WP_123789612.1	helix-turn-helix domain-containing protein	Antitoxin
EGY20_RS09385	2055287..2055865	+	579	WP_060144520.1	HD domain-containing protein	Toxin
EGY20_RS09390	2055960..2057498	-	1539	WP_123789613.1	MFS transporter	-
EGY20_RS09395	2057676..2058596	+	921	WP_123789614.1	LysR family transcriptional regulator	-
EGY20_RS09400	2058643..2059782	-	1140	WP_123789615.1	enoyl-CoA hydratase/isomerase family protein	-
EGY20_RS09405	2059779..2060570	-	792	WP_123789616.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-172)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21312.02 Da
• Isoelectric Point: 5.0967

>T114231 WP_060144520.1 NZ_CP033748:2055287-2055865 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNLHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Nucleotide

• Length: 579 bp

>T114231 NZ_CP033748:2055287-2055865 [Burkholderia multivorans]
ATGAACCCCGACACGATCCGCGCACGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGTCG
CACGTCGTCCGGCCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGACAAGAACCTGCACGAACGCGACGACCTGCTCACGCTGACGGCCGCACTCGATCC
CGTGCTACGTAACGAGCTCGTCGCACTGTGGGACGAATACGATGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACGGATGCGGCACCGCTATTCAGCGCGATCCGCGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACAAACGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20339.31 Da
• Isoelectric Point: 8.5490

>AT114231 WP_123789612.1 NZ_CP033748:2054604-2055161 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT114231 NZ_CP033748:2054604-2055161 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCACACGCCGCCGCTGGGTCCGCAGCTGAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGCGCTATTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAACGCCTGCTCGCCGCGCGCCTCGACTCCGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGGG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTTGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGTCGATGCTGCTCGGCACGTCGCTGTGGCGCTATGCGACAGAAGAAATCGTCCGGATGGAAACCGCACTGG
ACACACTCGGCTGGCACGATTGCGCAGGACCGCCGAGCGTCGAATTCGACACCGGCACGAACGCATCGCGCGTCGTGCCG
ATCCACCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGATCGGCGGCACGGCTCGTCGAAACGCTGTAG