Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 1886708..1887399 | Replicon | chromosome |
Accession | NZ_CP033748 | ||
Organism | Burkholderia multivorans strain FDAARGOS_547 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | J4S1H9 |
Locus tag | EGY20_RS08640 | Protein ID | WP_006416197.1 |
Coordinates | 1886708..1887163 (-) | Length | 152 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A132F1C7 |
Locus tag | EGY20_RS08645 | Protein ID | WP_012216644.1 |
Coordinates | 1887160..1887399 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EGY20_RS08615 | 1881895..1882689 | + | 795 | WP_123789547.1 | AraC family transcriptional regulator | - |
EGY20_RS08620 | 1883130..1884080 | + | 951 | WP_105813873.1 | DMT family transporter | - |
EGY20_RS08625 | 1884276..1884851 | + | 576 | WP_105813851.1 | permease | - |
EGY20_RS08630 | 1884946..1885080 | - | 135 | WP_006396654.1 | entericidin A/B family lipoprotein | - |
EGY20_RS08635 | 1885313..1886608 | + | 1296 | WP_012216646.1 | aspartate carbamoyltransferase | - |
EGY20_RS08640 | 1886708..1887163 | - | 456 | WP_006416197.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
EGY20_RS08645 | 1887160..1887399 | - | 240 | WP_012216644.1 | Arc family DNA-binding protein | Antitoxin |
EGY20_RS08650 | 1887703..1889949 | + | 2247 | WP_035955274.1 | TonB-dependent siderophore receptor | - |
EGY20_RS08655 | 1889953..1890708 | + | 756 | WP_123789548.1 | sel1 repeat family protein | - |
EGY20_RS08660 | 1890705..1891388 | + | 684 | WP_012216641.1 | Fe2+-dependent dioxygenase | - |
EGY20_RS08665 | 1891794..1892033 | + | 240 | WP_006416205.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 152 a.a. Molecular weight: 16207.59 Da Isoelectric Point: 7.2060
>T114230 WP_006416197.1 NZ_CP033748:c1887163-1886708 [Burkholderia multivorans]
MILVDTNVIAEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFAVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK
MILVDTNVIAEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFAVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK
Download Length: 456 bp
>T114230 NZ_CP033748:c1887163-1886708 [Burkholderia multivorans]
ATGATCCTTGTTGATACGAACGTCATTGCCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
ACAGAACGTCGAGACGCTATTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGCTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTGGCGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGAGCAAGGCCTATGCGCGCATTCGCGCGCACGCCCGTGCCGGCGGCAACGCGATCGCGCCCGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCGTCGCAGGGCGCGCCGGTGCGCCAAGGTATCGCGTCGAAATGA
ATGATCCTTGTTGATACGAACGTCATTGCCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
ACAGAACGTCGAGACGCTATTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGCTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTGGCGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGAGCAAGGCCTATGCGCGCATTCGCGCGCACGCCCGTGCCGGCGGCAACGCGATCGCGCCCGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCGTCGCAGGGCGCGCCGGTGCGCCAAGGTATCGCGTCGAAATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8716.94 Da Isoelectric Point: 5.1133
>AT114230 WP_012216644.1 NZ_CP033748:c1887399-1887160 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE
Download Length: 240 bp
>AT114230 NZ_CP033748:c1887399-1887160 [Burkholderia multivorans]
ATGCCGGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACGGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTCGGAACCTTGCTGGCGG
AAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATTCAGCGTGACAAGACGCCAACCGATCCGATGAGCTTCGAATGA
ATGCCGGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACGGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTCGGAACCTTGCTGGCGG
AAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATTCAGCGTGACAAGACGCCAACCGATCCGATGAGCTTCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | J4S1H9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A132F1C7 |