Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1886708..1887399 Replicon chromosome
Accession NZ_CP033748
Organism Burkholderia multivorans strain FDAARGOS_547

Toxin (Protein)


Gene name vapC Uniprot ID J4S1H9
Locus tag EGY20_RS08640 Protein ID WP_006416197.1
Coordinates 1886708..1887163 (-) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132F1C7
Locus tag EGY20_RS08645 Protein ID WP_012216644.1
Coordinates 1887160..1887399 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY20_RS08615 1881895..1882689 + 795 WP_123789547.1 AraC family transcriptional regulator -
EGY20_RS08620 1883130..1884080 + 951 WP_105813873.1 DMT family transporter -
EGY20_RS08625 1884276..1884851 + 576 WP_105813851.1 permease -
EGY20_RS08630 1884946..1885080 - 135 WP_006396654.1 entericidin A/B family lipoprotein -
EGY20_RS08635 1885313..1886608 + 1296 WP_012216646.1 aspartate carbamoyltransferase -
EGY20_RS08640 1886708..1887163 - 456 WP_006416197.1 type II toxin-antitoxin system VapC family toxin Toxin
EGY20_RS08645 1887160..1887399 - 240 WP_012216644.1 Arc family DNA-binding protein Antitoxin
EGY20_RS08650 1887703..1889949 + 2247 WP_035955274.1 TonB-dependent siderophore receptor -
EGY20_RS08655 1889953..1890708 + 756 WP_123789548.1 sel1 repeat family protein -
EGY20_RS08660 1890705..1891388 + 684 WP_012216641.1 Fe2+-dependent dioxygenase -
EGY20_RS08665 1891794..1892033 + 240 WP_006416205.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16207.59 Da        Isoelectric Point: 7.2060

>T114230 WP_006416197.1 NZ_CP033748:c1887163-1886708 [Burkholderia multivorans]
MILVDTNVIAEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFAVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T114230 NZ_CP033748:c1887163-1886708 [Burkholderia multivorans]
ATGATCCTTGTTGATACGAACGTCATTGCCGAACCGCTGCGGCGCGAGCCGAGCGCGGCCGTGATCGAATGGCTCGACGC
ACAGAACGTCGAGACGCTATTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGCTGTCGCGGCGCTGCCGGAAGGGC
GCCGGCGGGACTGGCTGGCGCAAAGCATCGAGCATCGTGTCGTGCCGGTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCCGCGAGCAAGGCCTATGCGCGCATTCGCGCGCACGCCCGTGCCGGCGGCAACGCGATCGCGCCCGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAACGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCGTCGCAGGGCGCGCCGGTGCGCCAAGGTATCGCGTCGAAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8716.94 Da        Isoelectric Point: 5.1133

>AT114230 WP_012216644.1 NZ_CP033748:c1887399-1887160 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT114230 NZ_CP033748:c1887399-1887160 [Burkholderia multivorans]
ATGCCGGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCACGGGCGCAG
TACGGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGTTGTCGGAAGGGCGCGTGAAGCTCGGAACCTTGCTGGCGG
AAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATTCAGCGTGACAAGACGCCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J4S1H9

Antitoxin

Source ID Structure
AlphaFold DB A0A132F1C7

References