114227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1448514..1449048 Replicon chromosome
Accession NZ_CP033748
Organism Burkholderia multivorans strain FDAARGOS_547

Toxin (Protein)


Gene name parE Uniprot ID A0A1W0YQN7
Locus tag EGY20_RS06675 Protein ID WP_035954873.1
Coordinates 1448749..1449048 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J4RB90
Locus tag EGY20_RS06670 Protein ID WP_006413656.1
Coordinates 1448514..1448759 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EGY20_RS06655 1443574..1445277 + 1704 WP_123789366.1 VRR-NUC domain-containing protein -
EGY20_RS06660 1445274..1447574 + 2301 WP_123789367.1 ATP-dependent DNA helicase -
EGY20_RS06665 1447605..1448375 - 771 WP_006403543.1 helix-turn-helix domain-containing protein -
EGY20_RS06670 1448514..1448759 + 246 WP_006413656.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
EGY20_RS06675 1448749..1449048 + 300 WP_035954873.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EGY20_RS06680 1449157..1450458 - 1302 WP_006403538.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
EGY20_RS06685 1450683..1451990 - 1308 WP_006403537.1 shikimate transporter -
EGY20_RS06690 1452345..1453472 + 1128 WP_123789368.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11570.09 Da        Isoelectric Point: 7.3154

>T114227 WP_035954873.1 NZ_CP033748:1448749-1449048 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T114227 NZ_CP033748:1448749-1449048 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCGCTGGCGGAGGCCGACCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCGCTCGACCAGGCTGAGCGCTATATCGGCGAGCTGAGCGCGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGCCGCGCGGGCGGCAACTATTCGCGGTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8632.71 Da        Isoelectric Point: 6.4604

>AT114227 WP_006413656.1 NZ_CP033748:1448514-1448759 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT114227 NZ_CP033748:1448514-1448759 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTGGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCCCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1W0YQN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KUX0

References